Since the apoE4 allele is a risk factor or susceptibility gene in late-onset familial and sporadic AD, the mechanism of disease expression may involve metabolic effects that are isoform specific. Isoform-specific interactions of apoE therefore become critical in the mechanism of AD pathogenesis. Detailed characterization of the binding of the apoE isoforms with proteins and peptides relevant to the pathology of the disease may be critical in understanding disease pathogenesis. These critic...

Peter Pan is a fictional character created by Scottish novelist and playwright J. M. Barrie. A free-spirited and mischievous young boy who can fly and never grows up, Peter Pan spends his never-ending childhood having adventures on the mythical island of Neverland as the leader of the Lost Boys, interacting with fairies, pirates, mermaids, Native Americans, and occasionally ordinary children from the world outside Neverland. Peter Pan has become a cultural icon symbolizing youthful innocen...

Reproductive technology allows us to test embryos' genes before deciding whether to transfer them to a woman's uterus. Embryo selection raises many ethical questions but is virtually unregulated in the United States. This comprehensive study considers the ethical, medical, political, and economic aspects of developing appropriate regulation.

How will increased understanding of the human genome affect our ability to diagnose and treat disease? The subject of recombinant DNA technology is no longer limited to the research laboratory; it is being discussed in ever-widening medical circles. Introduction to Molecular Medicine is especially written for the physician who is not a genetics expert but wishes to understand this new science and find entry to the more specialized publications. The first chapters present t...

Complementary and alternative medicine encompasses a wide range of modalities, including acupuncture, herbs and supplements, naturopathy, and body and mind therapies. The use of these healing methods is increasing rapidly, and more and more patients are approaching primary care physicians with questions about them. The purpose of this issue is to help doctors understand the evidence supporting and refuting complementary and alternative medicine techniques so they can provide patients with ...

Atlas of Dermatology in Internal Medicine is the only concise text-atlas to cover the most common and most important cutaneous manifestations of systemic disease in children and adults. It features more than 150 clinical photographs that are accompanied by format-driven, clinically focused text on the diagnosis and management of cutaneous manifestations of connective tissue, pulmonary, renal, GI, endocrine, malignant, infectious, and HIV disease. There is also a separate chapter o...

This book is designed to present the clinical geriatric trends within general internal medicine and family practice, which practitioners often encounter in caring for their older adult patients. Chapters focus on increasingly difficult clinical decisions that practitioners have to make in caring for older adults, who often experience medical complications due to memory loss, physical disability, and multiple chronic conditions. Written by experts in geriatric medicine, each of these chapte...

One of the fascinations of psychiatry is that it is amenable to many different approaches. In seeking to account for mental disorder, for example, it is pos sible to explore the meaning and significance of symptoms in the psychody namic sense, to examine the social determinants of illness, or to adopt an es sentially biological viewpoint in investigating links between physiological and psychological dysfunction .. As a clinical discipline it may be practiced in the community, in the specia...

Addressing physical and psychosocial matters of survivorship prior to, during, and after anticancer treatment is central to a patient’s wellbeing. The MASCC Textbook of Cancer Supportive Care and Survivorship explores not only the diagnosis and treatment but also the increasingly recognized complex and ongoing symptoms experienced by long term cancer survivors. Significant advances have been made, designing strategies to manage the side effects and symptoms of treatment and to prevent them...

An estimated 21 million people are diagnosed each year with a major depressive disorder in the USA, Western Europe and Japan. The economic cost of depression and its impact on sufferers and those around them is enormous. There are numerous therapy choices available, which can be daunting for the clinician trying to achieve the best treatment regimen. Managing Depression in Clinical Practice provides a concise overview of the clinical manifestation, diagnosis and management of this...

In this updated fifth edition of the Atlas of Atherosclerosis and Metabolic Syndrome (formerly the Atlas of Atherosclerosis), the editors have compiled a comprehensive update on the field of atherosclerosis. This four-color atlas includes detailed legends and extensive reference listings for hundreds of illustrations, algorithms, schematics, and images. This new edition focuses more closely on metabolic syndrome, as well as comprehensively covering many other topics including diabetes and ...

This book is designed to present a comprehensive, state-of the-art approach to assessing and managing bariatric surgery and psychosocial care. Unlike any other text, this book focuses on developing a biopsychosocial understanding of patients’ obesity journey and psychosocial factors contributing to their obesity and its management from an integrated perspective.Psychiatric Care in Severe Obesity takes a 360 approach by covering the disease’s prevalence and relationship to p...