A reference on drug metabolism and metabolite safety in the development phase, this book reviews the analytical techniques and experimental designs critical for metabolite studies. It features case studies of lessons learned and real world examples, along with regulatory perspectives from the US FDA and EMA.• Reviews the analytical techniques and experimental designs critical for metabolite studies• Covers methods including chirality, species differences, mass spectrometry, ...

With a focus on case studies of R&D programs in a variety of disease areas, the book highlights fundamental productivity issues the pharmaceutical industry has been facing and explores potential ways of improving research effectiveness and efficiency.Takes a comprehensive and holistic approach to the problems and potential solutions to drug compound attritionTackles a problem that adds billions of dollars to drug development programs and health care...

Closing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the largestpharmaceutical companies worldwide. The first chapters trace the development of our understanding of drug metabolite toxicity, covering basic concepts and techniques in the process, while the second part details chemical toxicophores that are prone to reactive metabolite formation. This section also reviews the various drug-metabolizi...

In this new edition of a bestseller, all the contents have been brought upto-date by addressing current standards and best practices in the assessment and prediction of ADMET properties. Although the previous chapter layout has been retained, substantial revisions have been made, with new topics such as pro-drugs, active metabolites and transporters covered in detail in a manner useful to the Drug Discovery scientist. The authors discuss the parameters and processes important for the absor...

This revised and updated third edition of Best New Horror showcases some of the very best short stories and novellas published in 1991. In this vilifying volume you will rediscover terrifying tales by, amongst many others, Ramsey Campbell, Robert McCammon, Dennis Etchison, Elizabeth Hand, Michael Marshall Smith, Charles L. Grant, Joel Lane and Thomas Tessier, along with an overview of the year in horror by the editors and a nightmare necrology of those who kicked off this mortal coil durin...

Autumn approaches, and with it comes a time of dark magic. In this issue we celebrate the fantastical, the foreign and the fatalistic. We have kallikantzaroi on a mission, banana Popsicle munching bombs, alien friends happy to lend more than a hand, a band that really puts themselves into their music and part one of Flashlight, Knife and Flowered Crown, an electrifying, modern fairy tale.Poetry, flash fiction and keen illustration add variety to the mix. An Spanish interview of Jac...

Studies of Communication in the 2020 Presidential Campaign explores a wide range of communication elements, themes, and topics of the 2020 presidential election. The introduction provides a brief snapshot summarizing the role of more traditional elements of campaign communication as well as the newer elements of social media and journalistic practices that transformed the political landscape in 2020. Each chapter serves as a stand-alone study focusing on the role and function of c...

Being a PhD student is not easy. Navigating the highly competitive world of academia while working hard for little or no pay would be stressful for anyone—but it’s especially challenging for graduate students who are also parents.Featuring contributions from more than forty current and former graduate students raising children, Parenting While PhDing offers valuable advice for students and administrators. Parents will get practical recommendations on both child care and se...

The tragic events of September 11, 2001, forever altered the American landscape, both figuratively and literally. Immediately after the jets struck the twin towers of the World Trade Center, Dennis Smith, a former firefighter, reported to Manhattan’s Ladder Co. 16 to volunteer in the rescue efforts. In the weeks that followed, Smith was present on the front lines, attending to the wounded, sifting through the wreckage, and mourning with New York’s devastated fire and police departments.

This year marks the tenth anniversary of the attacks on the World Trade Center and the Pentagon, an occasion that is sure to be observed around the world. But among the memorials, political speeches, and news editorials, the most pressing consideration—and often the most overlooked—is the lives and well-being of the 9/11 first responders, their families, and the victims' families over the past decade.Dennis Smith, a former firefighter and the author of the bestselling Report fr...

An unforgettable journey through the daily lives of the brave men and women who have made saving lives their profession.Dennis Smith, author of Report from Engine Co. 82, traveled across the country talking to dozens of America’s firefighters to put together this powerful collection of their own descriptions of their most dramatic and intense experiences on the job. Their stories, compiled here, are timeless testimonies to the human capacity for heroism and nobility....

Do you desire a more meaningful study and prayer life? Do you feel the need to reach out to others for Christ? If so, you've come to the right place. This book contains 40 days of devotional studies designed to strengthen your relationship with Christ and enable you to lead others to Him.God wants to do something significant in your life, too. Not only does He long to draw you into closer fellowship with Him--He also wants to minister to others through you. And as you spend 40 amazing days wi...