A leading figure in immunology takes readers inside the remarkably powerful human immune system.Winner of the CHOICE Outstanding Academic Title of the Choice ACRLThe immune system has incredible power to protect us from the ravages of infection. Boosted by vaccines, it can protect us from diseases such as measles. However, the power of the immune system is a double-edged sword: an overactive immune system can wreak havoc, destroying normal tissue and causin...

This volume is divided into three sections. Section I deals with factors that regulate the development and maturation of T cells and B cells and lymphocyte traffic. The significance of C-kit, Bcl-6, IL-7, and Vav in the development of T and B lymphocytes is discussed. A role of lymphotoxins and VAP-I in trafficking of leucocytes is reviewed. Finally, the trafficking and homing characteristics of T cell and B cell subsets, and the regulation of these processes during the immune response, is...

There has been major growth in understanding immune suppression mechanisms and its relationship to cancer progression and therapy. This book highlights emerging new principles of immune suppression that drive cancer, and it offers radically new ideas about how therapy can be improved by attacking these principles. Following work that firmly establishes immune escape as an essential trait of cancer, recent studies have now defined specific mechanisms of tumor immune suppression. It also dem...

This is the eBook version of the printed book. This Element is an excerpt from Antibiotic Resistance: Understanding and Responding to an Emerging Crisis (9780131387737) by Karl Drlica and David S. Perlin. Available in print and digital formats.   What everyone needs to know about antibiotics: what they are, how they work, what they can do, and what they can’t do.  

How will increased understanding of the human genome affect our ability to diagnose and treat disease? The subject of recombinant DNA technology is no longer limited to the research laboratory; it is being discussed in ever-widening medical circles. Introduction to Molecular Medicine is especially written for the physician who is not a genetics expert but wishes to understand this new science and find entry to the more specialized publications. The first chapters present t...

This standard-setting textbook has defined the field of immunology since 1984, and is now in its Seventh Edition continuing to deliver the detailed, authoritative, and timely coverage readers expect. This comprehensive, up-to-date text is ideal for graduate students, post-doctoral fellows, basic and clinical immunologists, microbiologists and infectious disease physicians, and any physician treating diseases in which immunologic mechanisms play a role. Now full-color throughout the book’s ...

Printed book plus Pageburst access. You will receive a printed book and access to the complete book content electronically. Pageburst enhances learning not only by bringing world class content to your fingertips but also by letting you add to it, annotate it, and categorize it in a way that suits you. Pageburst frees you to spend more time learning and less time searching.Anatomy & Physiology for Midwives 3rd edition builds on the success of the first two editions...

Research in Crohn’s disease (CD) and ulcerative colitis (UC), together known as the inflammatory bowel diseases (IBD), has truly seen a revolution in the last 5-10 years. This book examines how these genetic discoveries have led to the identification of biological functions not previously associated with IBD pathophysiology (e.g. autophagy), how multiple genetic risk factors for IBD converge on given biological functions and that together the identified variants in these genes have predisp...

Calcium-Sensing Receptor provides an overview of various aspects of the calcium receptor's biochemistry, physiology and pathophysiology that is suitable both for those who have been working in the field of Ca2+0-sensing as well as those who are new to this discipline.Calcium-Sensing Receptor is the nineteenth volume published in the Endocrine Updates book series under the Series Editorship of Shlomo Melmed, MD.

Polymyalgia rheumatica (PMR) is a condition that causes pain and stiffness in the muscles around the, neck, shoulders, upper arms, hips, buttocks, or thighs. The term literally means "rheumatic type of pain in many muscles."Polymyalgia rheumatica is a medical condition which is potentially treatable. If it is diagnosed correctly and then lifestyle changes are made or the proper medication is taken to tackle it, it is a manageable condition and you can live a happy and normal life e...

This book identifies and analyzes the genetic basis of bone disorders in humans and demonstrates the utility of mouse models in furthering the knowledge of mechanisms and evaluations of treatments. The book is aimed at all students of bone biology and genetics, and with this in mind, it includes general introductory chapters on genetics and bone biology and more specific disease-orientated chapters, which comprehensively summarize the clinical, genetic, molecular genetic, animal model, fun...

This book focusses on the different types of immunotherapeutics that are currently being used and developed for the treatment of melanoma. In recent years, immunotherapy has revolutionized the treatment of metastatic melanoma and other types of cancer.Discussing treatment options for melanoma and the success of immunotherapy along with the challenges of immunotherapy, this book covers epidemiology, susceptibility genes, and treatment recommendations from Society for Immunotherapy o...