In Just Enough**, two-time World Series Champion and 2006 World Series MVP David Eckstein shares the valleys and mountaintops that shaped him—years defined not by trophies, but by perseverance, faith, family, and the belief that purpose is found in how you rise when life tells you no.**You don't need to be the biggest. You don't need to be the strongest. You just need to keep going.David Eckstein was never supposed to make...

The impacts of population growth, climate change, and water scarcity and variability on a country's economy or society, in addition to the sheer need to harness international rivers for domestic and regional purposes, have made the management of transboundary freshwater a subject of great import. Over the past several decades, research in various disciplines utilizing a variety of methodologies has explored these issues, focusing on freshwater's strategic importance as well as conflict, co...

“Like every Cardinals fan, I remember where I was when David Eckstein was named World Series MVP. What I didn’t know was the incredible amount of grit, determination, and perseverance it took for him to get there. His journey is the ultimate underdog story, proving that heart, preparation, and relentless work ethic can overcome even the longest odds.”—Andy Cohen"A page-turning sports memoir with a solid message."—Kirkus ReviewsIn JUST ENOUGH, two-time World...

DNA is the central repository of genetic information in the cell, yet it is under constant attack by chemical mutagens, radiation and other processes. Cells therefore put a great deal of resources into repairing any damage to this precious store. Mechanisms of DNA repair vary greatly in their level of complexity, from specific reversal mechanisms that involve a single protein, to sequential pathways that require many enzymes. But at the heart of all these mechanisms lie proteins that recog...

**'**Magisterial . . . you reach the end of this profound, revealing book rewarded. West shows how scientific method helps to peel back the hidden reality of our world' MATTHEW SYED, THE TIMESGeoffrey West's research centres on a quest to find unifying principles and patterns connecting everything, from cells and ecosystems to cities, social networks and businesses.Why do organisms and ecosystems scale with size in a remarkably...

Biobanking, an emerging field supported by academia, industry and health administrators alike, is distinctly different today from the practice that once defined it. The science of Biobanking, which initially involved simply storing blood or tissue samples in a freezer, is now a highly sophisticated field of research, and expected to grow exponentially over the next decade or two. This book aims to serve the purpose of further enriching the available literature on Biobanking, by offering un...

The chapters of Studies on Periodontal Disease comprise four parts. Part 1 provides basic sciences from the general to the particular. The findings of cell culture and animal models supply the mechanism between periodontal disease and oxidative stress. In part 2, human clinical studies are mainly addressed. The effects of periodontal therapy on circulating oxidative stress are also discussed. The relationships between periodontal disease and systemic diseases are examined in part ...

This volume gives an overview of state of the art technologies and future developments in the field of preclinical pharmaceutical research. A balanced mix of experts from academia and industry give insight in selected new developments in the drug discovery pathway. The topics cover the different parts of the drug discovery process, starting with new developments in the target identification and validation area. The lead generation part as a next step focuses on the requirements and technol...

This book provides an overview of the advances on nanostructured celullose from different obtaining forms: natural plants and bacterial microorganisms. It gives the reader an introduction of cellulose focusing in nanosize particles, its potential applications and future perspectives. The potential use of cellulose in the biomedical field is highlighted.

This volume thoroughly explores of the functional role of microRNAs in cancer. It not only expertly describes the molecular mechanisms underlying the malignant transformation process but also compiles cutting-edge research on microRNAs in several forms of cancer, including colorectal cancer, pancreatic cancer, leukemia/lymphoma, prostate cancer, lung cancer, ovarian cancer, and bone cancer. Distinguished experts, currently working in prestigious institutions, elegantly discuss these fundam...

This book provides an overview of single-cell isolation, separation, injection, lysis and dynamics analysis as well as a study of their heterogeneity using different miniaturized devices. As an important part of single-cell analysis, different techniques including electroporation, microinjection, optical trapping, optoporation, rapid electrokinetic patterning and optoelectronic tweezers are described in detail. It presents different fluidic systems (e.g. continuous micro/nano-fluidic devic...