This book provides a comprehensive, up-to-date, and practical introduction to the estimand framework and its application in clinical trials. Since its introduction by the International Council for Harmonisation (ICH) through the E9(R1) guideline in 2019, the estimand framework has led to a significant shift in the design, conduct, analysis, and interpretation of clinical trials. By explicitly aligning trial objectives with the clinical question of interest—and by carefully accounting for i...

Higee Chemical Reaction Engineering systematically discusses the fundamentals, principles, and methods of molecular mixing and reaction process intensification. The book demonstrates the implementation approach, process, and effectiveness of Higee chemical reaction engineering through novel industrial case studies that help industrial technicians select reaction intensification technology route more scientifically. Sections cover the innovation and development process of Higee chemical rea...

This book is a collection of academic articles selected from papers published in the Chinese journal Education Research in 2023. Educational Research is an authoritative journal in the field of education in China. It was first published in 1979 and is a national, comprehensive, and theoretical journal of education research. This book presents 20 important educational research articles, and covers various topics such as pedagogy, educational policies, teacher education, vocational education...

The recent and dramatic development of China’s economy and international political muscle is especially pronounced in the country’s video game industry. Now the largest of its kind in the world by gross revenue, the Chinese video game industry impacts every player in the global game market and has begun to directly influence the nature of the video game medium itself. From its conceptualization of the player as a category and commodity, to its approach to the design, development, and marke...

Advanced Statistics in Regulatory Critical Clinical Initiatives is focused on the critical clinical initiatives introduced by the 21st Century Cure Act passed by the United States Congress in December 2016. The book covers everything from the outline of the initiatives to analysis on the effect on biopharmaceutical research and development. Advanced Statistics in Regulatory Critical Clinical Initiatives provides innovative ways to resolve...

HANDBOOK of Fruit and Vegetable FlavorsA global PERSPECTIVE on the latest SCIENCE, TECHNOLOGY, and APPLICATIONSThe demand for new flavors continues to rise. Today’s consumers want interesting, healthy, pleasurable, and exciting taste experiences, creating new challenges for today’s food and flavor scientists. Fortunately, they can turn to this comprehensive reference on the flavor science and technology of fruits, vegetables, spices, and oi...

This book reviews the history and development of rhizobial ecology (diversity, function and interactions with the biotic and abiotic environments), evolution (genome diversification, systematics of symbiotic genes) and application. Further, it describes the new concept of rhizobia, the latest systematic methods, biogeographic study methods, and genomic studies to identify the interactions between rhizobia, legumes and environments. To enable readers to gain a comprehensive understanding of...

A comprehensive overview of both traditional and current knowledge on the health effects of plant based antioxidants, this book reviews medicinal and aromatic plants from around the world. It covers the different sources of antioxidants including essential oils, algae and marine microorganisms, as well as the role of abiotic and biotic stresses, endophytes, transgenic approaches in scavenging ROS and antioxidant plants used in different therapeutic systems.

In this book, we collected recent results on the control of underactuated mechanical systems subject to internal uncertainties and external disturbances. The strategy developed is so universal that it is not restricted to a specific system but a large class of underactuated systems. Several benchmark systems are studied in this book, including detailed literature review, system dynamics derivation, control problem formulation, and simulation verification. The control strategy developed in ...

A great need exists for valuable information on factors affecting the quality of animal related products. The second edition of Handbook of Meat, Poultry and Seafood Quality, focuses exclusively on quality aspects of products of animal origin, in depth discussions and recent developments in beef, pork, poultry, and seafood quality, updated sensory evaluation of different meat products, revised microbiological aspects of different meat products. Also, included are new chapters on p...

Engineers and scientists alike will find this book to be an excellent introduction to the topic of porous materials, in particular the three main groups of porous materials: porous metals, porous ceramics, and polymer foams. Beginning with a general introduction to porous materials, the next six chapters focus on the processing and applications of each of the three main materials groups. The book includes such new processes as gel-casting and freeze-drying for porous ceramics and self-prop...

Iptycenes Chemistry: From Synthesis to Applications provides a comprehensive overview of the development of iptycene chemistry in the past seventy years. This book covers: (1) the basic nomenclature and general properties of iptycenes and their derivatives; (2) the synthesis and functionalization reactions of triptycenes, pentiptycenes, higher iptycenes, heterotriptycenes, and homotriptycenes; (3) the methods for the preparation of iptycene-based polymers with different types; and (4) the ...