Targeting Cell Survival Pathways to Enhance Response to Chemotherapy encompasses recently developed molecular targeting agents and approaches that suppress cell survival signaling. Cell survival signaling attenuates the effectiveness of conventional chemotherapy and numerous mechanisms have been described, and continue to be described, which contribute to cell survival in the face of chemotherapy treatment. Key pathways leading to chemoresistance emanate from growth factor receptors, PI3K,...

Contrary to what many philosophers believe, Calvinism neither makes the problem of evil worse nor is it obviously refuted by the presence of evil and suffering in our world. Or so most of the authors in this book claim. While Calvinism has enjoyed a resurgence in recent years amongst theologians and laypersons, many philosophers have yet to follow suit. The reason seems fairly clear: Calvinism, many think, cannot handle the problem of evil with the same kind of plausibility as other more p...

The Chronicles of Pirates gathers nine landmark accounts of maritime outlawry into a capacious history of piracy, balancing documentary narrative, biography, adventure writing, and later historical reconstruction. Moving from the buccaneering Caribbean to the wider Atlantic and Mediterranean worlds, it tests the distance between popular legend and archival reality. Narratives of sea raids, mutiny, colonial conflict, and notorious captains illuminate piracy not merely as romance, but as a v...

Embark on a journey to colonial India in E. M. Forster's captivating novel, "A Passage to India." Step into the bustling city of Chandrapore, where social barriers simmer beneath the surface. Meet Adela Quested, an Englishwoman yearning for authenticity, and Dr. Aziz, a charming Indian doctor caught in a web of misunderstanding. A mysterious incident in the Marabar Caves shatters their fragile connection, sparking a trial that inflames racial tensions. Can true friendship bridge the cultur...

Informative and entertaining essays on the accents, dialects, and speech patterns particular to AlabamaThomas E. Nunnally’s fascinating volume presents essays by linguists who examine with affection and curiosity the speech varieties occurring both past and present across Alabama. Taken together, the accounts in this volume offer an engaging view of the major features that characterize Alabama’s unique brand of southern English.Written in an accessible mann...

This collection centers on the remarkable life and career of the writer and actor Elizabeth Inchbald (1753–1821), active in Great Britain in the late eighteenth century. Inspired by the example of Inchbald’s biographer, Annibel Jenkins (1918–2013), the contributors explore the broad historical and cultural context around Inchbald’s life and work, with essays ranging from the Restoration to the nineteenth century. Ranging from visual culture, theater history, literary analyses and to histor...

This book introduces contemporary Buddhists from across Asia and from various walks of life. Eschewing traditional hagiographies, the editors have collected sixty-six profiles of individuals who would be excluded from most Buddhist histories and ethnographies. In addition to monks and nuns, readers will encounter artists, psychologists, social workers, part-time priests, healers, and librarians as well as charlatans, hucksters, profiteers, and rabble-rousers—all whose lives reflect changes...

In 2016, at the age of 25, 1st Lt. Daniel Johnson found himself dropped into Iraq with a mission he wasn't prepared for: being the only military journalist on the ground with the "Black Hearts" of the 101st Airborne Division as it worked to defeat the Islamic State of Iraq and the Levant, battling threats ranging from drones, information warfare, and chemical attacks. With no photojournalism experience or training, the young man soon found himself in a situation over his head as the confli...

Self-discipline. Life management - 3 steps to create a life plan and How to Master yourself effectively----- Why don't you succeed? Do you want to grow well? -----Life management is something you should not miss then. Good life management ensures that every aspect of your life grows as it should. Without good life management, it’s easy to leave out some aspects of your personal growth while overemphasizing the others.Life man...

Ex space Marine Jonah and his co-pilot Alphius rove the Galaxy, just trying to get by. Drawn into one crazy adventure after another, they forge a crew of misfits into a family that must face the darkest parts of the universe together. Space-Mullet is a richly detailed, accessible sci-fi world with heartfelt characters and an unforgettable story.

Discover the action-packed continuation of the story, which takes place three months after the events of issue 1. Follow Derek as he struggles with his past while trying to balance his personal life with his newfound responsibilities. Delve deeper into Saint's extraordinary abilities and learn why he is crucial to his city's well-being and his divine mission. This thrilling ebook is 80 pages long and strives to keep you on the edge of your seat.

Textual Cacophony explores the behaviors and routines of communication within anonymous internet culture in Japan. Focusing on the video sharing website Niconico, social media aggregation sites, and the notorious 2channel message board, Daniel Johnson uncovers these sites' complex cultures of writing that obscure meaning through playful and opaque forms of deviant script and overwhelming waves of text. Those practices conflate language with images...