This volume in the AAPS Advances series covers various quality, safety and clinical aspects of drug development that are relevant to new and/or generic drugs containing a complex mixture of molecules. Specific topics discussed include: raw materials sourcing; manufacturing controls; characterization; identification of critical product quality components and attributes; identification of impurities, particularly as they bear on toxicity and immunogenicity; clinical trial study design consid...

The language of Poetry is an art that most of us attempt at some point in our lives. Although its commonplace exposure has been somewhat marginalised in today’s often fast-paced lives we all recognise good verse that can empathise with our thoughts or open us up to experience new things in new ways, to better understand and to enjoy the many strands of our lives.But finding a starting point can be overwhelming, even off-putting, so in this series we offer up our Top 10 classic poet...

For PR Industry BeginnersAmy Rosenberg's first book, A Modern Guide to Public Relations, is a no-frills guide to everything you wish you learned in college or on-the-job about launching a PR career or adding new skills to your marketing position.Through an honest, boots-on-the-ground account of two decades working in PR, Rosenberg teaches you how to work with bloggers, podcasters and traditional media to land earned media coverage, increase website rankings and bui...

PR That Works SmarterMost PR playbooks are written for billion-dollar brands with massive teams and corporate budgets. They throw ideas around without explaining how to get them done - and who says old-school media coverage will even benefit you?Today's approach needs to be practical, scalable and easier to execute. Amy Rosenberg delivers by ingraining SEO, content marketing and thought leadership into the very fiber of PR. Pouring decades of experience int...

“Biobetters: Protein Engineering to Approach the Curative” discusses the optimization of protein therapeutic products for treatment of human diseases. It is based on the fact that though numerous important therapeutic protein products have been developed for life threatening and chronic diseases that possess acceptable safety and efficacy profiles, these products have generally not been reexamined and modified for an improved clinical performance, with enhancements both to safety and effic...

Agnes Hussein, descendant of the last sultan of Singapore and the last surviving member of her immediate family, has grown up among her eccentric relatives in the crumbling Kampong Glam palace, a once-opulent relic given to her family in exchange for handing over Singapore to the British.Now Agnes is seventeen and her family has fallen into genteel poverty, surviving on her grandfather’s pension and the meager income they receive from a varied cast of boarders. As outside forces co...

For fans of What Belongs to You by Garth Greenwell and The Futures by Anna Pitoniak, a soul-piercing debut that explores the intertwining of past and present, queerness, and coming of age in uncertain times.Willa's darkness enters Hesper's light late one night in Brooklyn. Theirs is a whirlwind romance until Willa starts to know Hesper too well, to crawl into her hidden spaces, and Hesper shuts her out. She runs, following her fractured family bac...

Cooper, Emmanuelle, Henry, and Nick used to be inseparable. They grew up together, went to school together, and shared all of their major milestones together. But they’ve grown apart over the years, so when they all return to their small hometown as adults, it’s incredibly awkward between them. Emmanuelle starts working in the city-planning office, finally becoming part of her father’s professional world. Henry is as perfect as ever, teaching English at the local high school and quickly be...

The stereotypical image of a poet is one of unknown talent starving in a garret and who’s faithfulness and legacy to the art is discovered only after their death.In some cases this is undoubtedly true, but Poets being human and with the same building blocks of physical and mental health as the rest of us, also had the same afflictions and problems as the rest of us.The long roll call of names and the truncated legacies that were left behind is filled with these lost talents...

The 2006 Nobel Prize in Physiology or Medicine was awarded to Andrew Z. Fire and Craig C. Mello for their discovery of RNA interference (RNAi). RNAi is a biological process in which RNA molecules can silence (inhibit) or up- or down-regulate gene expression, typically by causing the destruction of specific messenger RNA (mRNA) molecules. This collection of articles begins with an introduction to RNAi, and proceeds to describe uses of this technology in various approaches to disease treatme...

Oncology Book of 2011, British Medical Association's Medical Book AwardsAwarded first prize in the Oncology category at the 2011 BMA Medical Book Awards, Monoclonal Antibody and Peptide-Targeted Radiotherapy of Cancer helps readers understand this hot pharmaceutical field with up-to-date developments. Expert discussion covers a range of diverse topics associated with this field, including the optimization of design of biomolecules and radiochemistry, cell ...

Most of the antibiotics now in use have been discovered more or less by chance, and their mechanisms of action have only been elucidated after their discovery. To meet the medical need for next-generation antibiotics, a more rational approach to antibiotic development is clearly needed.Opening with a general introduction about antimicrobial drugs, their targets and the problem of antibiotic resistance, this reference systematically covers currently known antibiotic classes, their m...