First Published in 2002. In common usage, the term "depression" can refer to the state of being sad or blue, but it also signifies a serious clinical syndrome that affects approximately 10 percent of people at some point in their lives. This clinical syndrome may occur as a primary illness or as a complication of ("secondary to") another mental disorder such as schizophrenia, a medical condition such as hypothyroidism, or the effects of a drug. Based on studies of clinical courses and outc...

First published in 2002. Obsessive-compulsive disorder (OCD) and Tourette's syndrome (TS) are treated together in this volume because symptoms of each often co-occur and because there are substantial overlaps in genetic risks and possibly in the neurobiology underlying these disorders.

There has been a revolution in our understanding of mental illness and its effect on society. The science of mental illness has made enormous strides based on the just-completed decade of the brain and is poised to make quantum progress again based on the completion of the Human Genome Project. These and other developments are covered in this new multi-volume set, which brings together in one in-depth collection the most significant recent scholarship on mental and addictive disorders.

GAIN A COMPLETE UNDERSTANDING OF NERVOUS SYSTEM FUNCTION AND ITS RELATIONSHIP TO HUMAN NEUROLOGIC DISORDERSMolecular Neuropharmacology first reviews the fundamental biochemistry of the functioning nervous system and then describes how nerve cells communicate with one another through numerous types of neurotransmitters involving amino acids, monoamines, neuropeptides, and neurotrophic factors, among several others.The neuropharmacology and neural circuits that und...

Introduction to Neuropsychopharmacology expands on the molecular and cellular foundations of the classic Biochemical Basis of Neuropharmacology, Eighth Edition (Cooper, Bloom, and Roth) by now including the behavioral methods used to study psychoactive drugs in experimental animals and in humans. Authored by four founders of modern neuroscience, this concise and comprehensive text covers the current series of medications used to treat diseases of the brain and nervous sys...

The revolution in psychiatry that began in earnest in the 1960s led to dramatic advances in the understanding and treatment of manic-depressive illness. Hailed as the most outstanding book in the biomedical sciences when it was originally published in 1990, Manic-Depressive Illness was the first to survey this massive body of evidence comprehensively and to assess its meaning for both clinician and scientist. It also vividly portrayed the experience of manic-depressive illness from the per...

As many as 35-40% of patients afflicted with Major Depressive Disorder (MDD) are treatment resistant, a situation that places a massive emotional and financial burden on society and challenges the mental health profession to develop new treatment paradigms and practices. Even the most astute clinicians can be frustrated when treatment options fail to be effective or work for only a brief time, leaving them to wonder what course to pursue next. Treatment Resistant Depression: A Roadmap for ...

Psychoneuroimmunology is the study of interactions among behavioral, neural and endocrine, and immunologic processes of adaptation. These two volumes provide a clearly written, extensively referenced summary of some of the behavioral, neural and endocrine regulators of immune responses and immunologically mediated disease processes and of the behavioral and neuroendocrine effects of immune system activity. Several chapters expand upon topics reviewed in earlier editions of this series; mos...

Pain Genetics: Basic to Translational Science is a timely synthesis of the key areas of research informing our understanding of the genetic basis of pain. The book opens with foundational information on basic genetic mechanisms underlying pain perception and progresses recently discovered complex concepts facing the field. The coverage is wide-ranging and will serves as an excellent entry point into understating the genetics of pain as well as providing a single resource for estab...

Executive dysfunction occurs in many clinical conditions and has significant impact on multiple facets of life. This book summarizes executive function and dysfunction for practitioners, researchers and educators, covering lifespan development, assessment, impact and interventions. Drawing together clinical, neurobiological and developmental viewpoints, the authors summarize the latest research findings in practical and applied terms, and review conceptual approaches to assessing and ident...

Neuroendocrinology, the discipline concerned with how the nervous system controls hormonal secretion and how hormones control the brain, is pivotal to physiology and medicine. Neuroendocrinology has disclosed and underpins fundamental physiological, molecular biological and genetic principles such as the regulation of gene transcription and translation, the mechanisms of chemical neurotransmission and intracellular and systemic feedback control systems. Reproduction, growth, stress, aggres...

The reference is a broad-ranging review of Alzheimer's disease and other dementias from both basic and clinical neuroscience perspectives; it provides scientists and medical professionals with an extensive introduction and an up-to-date review of cutting-edge scientific advances.Brings the reader up-to-date with cutting-edge developments in this exciting and fast-paced fieldSummarizes the most recent developments in the fields of Alzheimer's disease and dementia