With the dramatic increase in RNA 3D structure determination in recent years, we now know that RNA molecules are highly structured. Moreover, knowledge of RNA 3D structures has proven crucial for understanding in atomic detail how they carry out their biological functions. Because of the huge number of potentially important RNA molecules in biology, many more than can be studied experimentally, we need theoretical approaches for predicting 3D structures on the basis of sequences alone. Thi...

Aerilyn wasn't expecting much from an already lousy night. What seemed to be a routine meetup with a John at a rundown motel turned into a roller-coaster of mortal danger. She is introduced to a world of organized crime, riding shot gun with the deadliest person she has ever encountered. The tall, dark, and mysterious contract killer is a woman with a secret. Now they are both being hunted by one of the most powerful families on the East Coast. This High-Octane Sapphic Mafia Romance will t...

Aerilyn wasn't expecting much from an already lousy night. What seemed to be a routine meetup with a John at a rundown motel turned into a roller-coaster of mortal danger. She is introduced to a world of organized crime, riding shot gun with the deadliest person she has ever encountered. The tall, dark, and mysterious contract killer is a woman with a secret. Now they are both being hunted by one of the most powerful families on the East Coast. This High-Octane Sapphic Mafia Romance will t...

Aerilyn wasn't expecting much from an already lousy night. What seemed to be a routine meetup with a John at a rundown motel turned into a roller-coaster of mortal danger. She is introduced to a world of organized crime, riding shot gun with the deadliest person she has ever encountered. The tall, dark, and mysterious contract killer is a woman with a secret. Now they are both being hunted by one of the most powerful families on the East Coast. This High-Octane Sapphic Mafia Romance will t...

Aerilyn wasn't expecting much from an already lousy night. What seemed to be a routine meetup with a John at a rundown motel turned into a roller-coaster of mortal danger. She is introduced to a world of organized crime, riding shot gun with the deadliest person she has ever encountered. The tall, dark, and mysterious contract killer is a woman with a secret. Now they are both being hunted by one of the most powerful families on the East Coast. This High-Octane Sapphic Mafia Romance will t...

Specially designed computer software is revolutionizing procedures for structured or rational drug design and discovery. The Guidebook on Molecular Modeling in Drug Design serves as a manual for the analysis ofmolecular structure and the correlation of these structures with pharmacological reactions. Intended as an introductory guide for advanced students and professionals with an interest in computer-assisted modeling for drug design and discovery, this bookwill also be of interest to med...

Kinetic studies of enzyme action provide powerful insights into the underlying mechanisms of catalysis and regulation. These approaches are equally useful in examining the action of newly discovered enzymes and therapeutic agents. Contemporary Enzyme Kinetics and Mechanism, Second Edition presents key articles from Volumes 63, 64, 87, 249, 308 and 354 of Methods in Enzymology. The chapters describe the most essential and widely applied strategies. A set of exercises and problems is include...

This book evolved from an interdisciplinary graduate course entitled 'Molecular Modeling' developed at New York University. Its primary goal is to stimulate excitement for molecular modeling research while providing grounding in the discipline. Scientists who wish to enter, or become familiar with, the field of biomolecular modeling and simulation may benefit from the broad coverage of problems and approaches.

Frontiers in Computational Chemistry, originally published by Bentham and now distributed by Elsevier, presents the latest research findings and methods in the diverse field of computational chemistry, focusing on molecular modeling techniques used in drug discovery and the drug development process. This includes computer-aided molecular design, drug discovery and development, lead generation, lead optimization, database management, computer and molecular graphics, and the development of n...

"Disruption of Protein-Protein Interfaces" reviews the latest developments and future perspectives in drug discovery at protein-protein interfaces. The authors detail experimental and computational tools to tackle the subject and highlight the contribution of the Italian research community to the field. Evidence shows that blocking or modulating protein-protein interactions might lead to the development of useful new drugs. Consequently, in recent years great effort has been dedicated to u...

In this monograph, the importance of fluctuations for biological reactions is discussed from various points of view. Understanding the biological reactions at the molecular level is one of the major targets in many scientific fields, including not only basic biology but also physics, physical chemistry, and medical science. One of the key factors in the process is “fluctuation”. Thermal energy causes biological molecules to be in constant fluctuation even while they are carrying out their ...

This book discusses how biological molecules exert their function and regulate biological processes, with a clear focus on how conformational dynamics of proteins are critical in this respect. In the last decade, the advancements in computational biology, nuclear magnetic resonance including paramagnetic relaxation enhancement, and fluorescence-based ensemble/single-molecule techniques have shown that biological molecules (proteins, DNAs and RNAs) fluctuate under equilibrium conditions. Th...