How did a young native of the American South, raised in an era of racism and segregation, rise to a highly decorated position at the forefront of molecular biology research? Up from Mississippi follows the remarkable career of James Darnell, a major player in some of the discoveries that illuminated our understanding of gene expression, paving the way for medical technologies—including some COVID-19 vaccines—based on messenger RNA. Darnell relates not only the circumstances and details of ...