Concepts on the Causal Genesis of Human Intestinal Tumors The action of chemical substances has a significant role in the genesis of human tumors. It is assumed that most human tumors are induced by exogenous chemical noxae (Schmahl, 1970;Heidelberger, 1975; and others). In the course of intensive efforts to discover the principles of tumor etiology, important insights have resulted in recent years. These are that chemical carcinogens do not only arise as products of our tech nologic...

This book discusses canine and feline skin cytology and the importance of this diagnostic tool in interpreting skin lesions. With more than 600 clinical and cytological color pictures, it explains the cytological patterns observed in all cutaneous inflammatory and neoplastic lesions in cats and dogs, as well as cutaneous metastasis of non-primary skin neoplasms. The first part of the book describes cell morphology and cytological patterns, providing an overview of the normal structure of t...

The publication of this third edition of the definitive text on clinical forensic medicine comes at an exciting time for a subject now gaining recognition as a speciality in the medical establishment. This growing acknowledgement reflects the fact that increasing numbers of health professionals are becoming engaged in general forensic services. Nurses and paramedics are more involved than ever in custody care, while nurses themselves are conducting more examinations in cases involving alle...

In the forensic context it is quite common for nonhuman bones to be confused with human remains and end up in the medical examiner or coroner system. It is also quite common for skeletal remains (both human and nonhuman) to be discovered in archaeological contexts. While the difference between human and nonhuman bones is often very striking, it can also be quite subtle. Fragmentation only compounds the problem. The ability to differentiate between human and nonhuman bones is dependent on t...

The Frozen Section Library series provides concise, user-friendly, site specific handbooks that are well illustrated and highlight the pitfalls, artifacts and differential diagnosis issues that arise in the hurried frozen section scenario.Written by expert surgical pathologists, Frozen Section Library: Endocrine Organs presents common and practical problems including follicular adenoma versus follicular carcinoma, papillary thyroid carcinoma versus reactive change and free...

This book provides a fundamental understanding of immunopathology and immunopathologic processes, with particular attention to nonclinical toxicology studies. Chapters provide organ system–based summaries of spontaneous pathology and common responses to xenobiotics. A companion volume*, Immunopathology in Toxicology and Drug Development: Volume 1, Immunobiology, Investigative Techniques, and Special Studies*, offers an overview of general immunobiology, cells of the immune system, signalin...

The theory of the sick lobe states that breast carcinoma is a lobar disease developing most often within a single lobe, meaning that, at an early stage, breast carcinoma occupies a limited, anatomically well-defined portion of the breast. This theory unites observed patterns from the genetic, developmental and morphological perspectives, into an overall concept. Breast Cancer: A Lobar Disease, presents this hypothesis and its consequences. The body of evidence, pro and contra, generated in...

Neurosurgery o/the Future: Computers and Robots in Clinical Neurosurgical Practice and in Training - a Philosophical Journey into the Future Many present day neurosurgeons believe that they already obtain good results in operative surgery with the benefit of the operating microscope and other aids which have become available in the last three decades and that the introduction of computers and robots to the operating theatre is superfluous. However, it is clear from analogy with the functio...

In commissioning this volume of Current Topics in Pathology, the editor of the series, Prof. Sir Colin Berry, asked me to produce something "which is aimed at the general pathologist but from the point of view of the neuropathologist who knows what is not being done well". This was easier said than done. Many aspects of neuropathology are encountered only infrequently in general pathology and are best dealt with by re ferral of material to a specialist unit. Others need more extensive inve...

The past 20 years have seen a surge of research into colorectal cancer, which is a reflection of the need to improve our methods of treating patients suffering from this increasingly common form of cancer. Greater knowledge of the basic mechanisms involved in colorectal carcinogenesis is an essential prerequisite to improvements in cancer prevention. In this volume the editors have brought together an impressive list of experts to cover the epidemiology, pathophysiology, morphology and bas...

Atlas on the Human Testis: Normal Morphology and Pathology presents histological illustrative material from paraffin and semi-thin sections of the human testis which are routinely used in the assessment of testicular morphology, allowing an early detection of carcinoma in situ and more advanced pathological changes of the testicular parenchyma. The early detection of cancer in situ is based on the careful morphological investigation of the biopsy and immunohistoc...

This issue of Surgical Pathology Clinics, edited by Rhonda K. Yantiss, will focus on Gastrointestinal Pathology: Common Questions and Diagnostic Dilemmas. Topics in this issue include, but are not limited to: Other forms of esophagitis; Diagnosis and management of Barrett-related neoplasia in the modern era; Patterns of gastric injury; Practical approach to the flat duodenal biopsy specimen; Chronic colitis in biopsy samples; Mucosal biopsy following bone marrow transplantation; The many f...