Applying new technologies, presenting your experience, and, of course, thinking of your current practice in the light of new evidence, needs some understanding of clinical research methodology.This book is not a textbook, but a brief guidance for clinical research practice. It aims at bridging the different points of view of statisticians and clinicians, but does not replace personal meetings and discussions between both professions at the earliest step of a clinical study. We hope...

A pocket-sized handbook for all the major outcomes instrumentsWhat outcomes are important to patients and clinicians?How is a specific instrument scored?Has it undergone reliability testing?In what population was it validated, and how did it perform?This pocket-sized handbook, covering all the major musculoskeletal outcomes instruments in use today, answers these questions and more. Key concepts like reliability, validity, a...

Spine Outcomes Measures and Instruments evaluates and summarizes more than 100 outcomes instruments for the spine and its associated diseases. The book addresses important questions such as:What outcomes are important to patients and clinicians?Which questions are used to build a specific outcomes instrument?How is a specific instrument scored?Is it completed by the clinician or the patient?Has the instrument u...

The new, completely revised, and updated edition of this classic text --sponsored by the International Epidemiological Association (IEA) and previously edited by John Last-- remains the definitive dictionary in epidemiology worldwide. In fact, with contributions from over 220 epidemiologists and other users of epidemiology from around the globe, it is more than a dictionary: it includes explanations and comments on both core epidemiologic terms and on other scientific terms relevant to all...

Team-Based Learning (TBL) is a well-defined pedagogy that combines individual pre-class guided learning with small group in-class active learning. TBL emphasizes the importance of individual accountability, team-work, critical thinking, and the application of basic, fundamental concepts in solving real world problems. The role of the instructor is to clearly articulate the learning outcomes and objectives, create challenging problems for students to solve, and probe their reasoning in reac...

Biostatistics, Second Edition, is a user-friendly guide on biostatistics, which focuses on the proper use and interpretation of statistical methods. This textbook does not require extensive background in mathematics, making it user-friendly for all students in the public health sciences field. Instead of highlighting derivations of formulas, the authors provide rationales for the formulas, allowing students to grasp a better understanding of the link between biology and statistics. The mat...

Evidence-based medicine aims to apply the best available evidence gained from the scientific method to medical decision making. It is a practice that uses statistical analysis of scientific methods and outcomes to drive further experimentation and diagnosis. The profusion of evidence-based medicine in medical practice and clinical research has produced a need for life scientists and clinical researchers to assimilate biostatistics into their work to meet efficacy and practical standards. P...

Applied Survival Analysis Using R covers the main principles of survival analysis, gives examples of how it is applied, and teaches how to put those principles to use to analyze data using R as a vehicle. Survival data, where the primary outcome is time to a specific event, arise in many areas of biomedical research, including clinical trials, epidemiological studies, and studies of animals. Many survival methods are extensions of techniques used in linear regression and categoric...

Over the years, medical informatics has matured into a true scientific discipline. Fundamental and applied aspects are now taught in various fields of health, including medicine, dentistry, pharmacy, nursing and public health. Medical informatics is also often included in the curricula of many other disciplines, including the life sciences, engineering and economics.Medical informatics is a complex and rapidly changing discipline. Relatively few books have been published on the sub...

LEARN THE EFFICIENT, EASY WAY TO CONDUCT MEDICAL RESEARCHPERFECT FOR ANYONE CONSIDERING A MEDICAL RESEARCH PROJECT!This concise handbook tells you everything you need to know about medical research. You will learn how to read, understand, and ultimately perform it.Medical Research Essentials walks you step by step through the entire research process, from how to read and critique an article, to presenting your own data. Filled with flowch...

This new book provides a unified, in-depth, readable introduction to the multipredictor regression methods most widely used in biostatistics: linear models for continuous outcomes, logistic models for binary outcomes, the Cox model for right-censored survival times, repeated-measures models for longitudinal and hierarchical outcomes, and generalized linear models for counts and other outcomes.Treating these topics together takes advantage of all they have in common. The authors poi...

Written for animal researchers, this book provides a comprehensive guide to the design and statistical analysis of animal experiments. It has long been recognised that the proper implementation of these techniques helps reduce the number of animals needed. By using real-life examples to make them more accessible, this book explains the statistical tools employed by practitioners. A wide range of design types are considered, including block, factorial, nested, cross-over, dose-escalation an...