Advances in medicine have made possible better treatments for widespread, familiar human illnesses like cancer, diabetes, and heart disease. Yet there are thousands of much less common diseases, most of genetic origin, each classed as “rare” because it afflicts only a small number of people. These patient groups were long ignored by a pharmaceutical industry that judged them too small to provide a return on the investment needed to develop an effective remedy. Yet these “orphaned” diseases...

It’s June 1953, and ten-year-old Marc Straus is in his mother’s car, getting sick from her cigarette smoke on his way to a Hebrew lesson. He and his younger brother, Stephen, are transferring from public school to a Yeshiva. His parents haven’t said why they’re transferring—the family isn’t religious. So all Marc knows is he’ll have to protect his brother. Stephen’s a delicate kid other kids pick on. Marc’s a street fighter who knows how to wall off the pain.So begins One-Legge...

Completely revised and updated, Treatment Wetlands, Second Edition is still the most comprehensive resource available for planning, designing, and operating wetland treatment systems. It provides engineers and scientists with a complete reference source that includes: detailed information on wetland ecology, design for consistent performance, site specific studies, estimated costs, construction guidance and operational control through effective monitoring. Case histories of operational wet...

**Narrated by Scott Wallace and converted with AI to Reid Hoffman's voiceInstant New York Times and USA Today Bestseller.Tech visionary and co-founder of Manas AI Reid Hoffman shares his unique insider’s perspective on an AI-powered future, making the case for its potential to unlock a world of possibilities."An essential companion." — Fei-Fei Li"An important read." —Bill Gates"Brilliant mind. Compassionate heart. Bold ideas…...

The contributors to Long Term use the tension between the popular embrace and legalization of same-sex marriage and the queer critique of homonormativity as an opportunity to examine the myriad forms of queer commitments and their durational aspect. They consider commitment in all its guises, particularly relationships beyond and aside from monogamous partnering. These include chosen and involuntary long-term commitments to families, friends, pets, and coworkers; to the care of ot...

Undefeated galactic heavyweight champion Korak the Cutter has defeated all challengers, destroying everyone in his path, but the wins aren't as easy as they used to be. After a decade of perfect fighting, his age is catching up with him. For a Quyth Warrior, that means he's slowing down, and speed is the name of the game in mixed martial arts. At this late stage in his career, he faces a nightmare savage and unpredictable Chiyal "The Heretic" North. As crime lords and promoters try to fix ...

THE DETECTIVE is a bit of back story for Frederico Esteban Guissepe Gonzaga and his search for the family of Quentin Barnes. THE DETECTIVE takes place from roughly March 2683, to March 2684. Where applicable, the chapters are named to map to the action in THE ALL-PRO (Book III in the Galactic Football League series). The story actually begins, however, on unknown dates during Book II, THE STARTER. In terms of the GFL timeline, THE DETECTIVE runs from roughly Week Seven of the 2683 regular ...

The Thousand-Year Spy opens in 1944 London, where, as Operation OVERLORD looms, the British Secret Service devises an audacious scheme: the false-flag recruitment of a German admiral who secretly is a communist. There isn’t much time. The admiral will be approachable only during the brief window when he travels to neutral Sweden at the head of a Nazi delegation. For the daring gambit to succeed, the British first must borrow from the Americans a linguistically brilliant yo...

Build Lasting Happiness and Connection in Just Weeks-Even If You've Struggled with Misunderstandings, Busy Schedules, or Digital Drama BeforeDo you ever feel like your messages are lost in translation, even with the person you love most?Are you tired of minor disagreements spiraling into days of silence or endless texting that only adds to the confusion?Do you wish you could break through the noise-on screens and IRL-and truly be heard, ...

In the quaint countryside, where rolling hills met whispering willows, there lived an extraordinary canine named Old Dog Spot. His once-glossy coat had faded to a silvery hue, and his wise eyes held a lifetime of adventures. As the sun began its golden descent, Spot embarked on a captivating journey, recounting tales of his youth, his encounters with mischievous squirrels, and his unwavering loyalty to his beloved master. With each paw print he left behind, he wove a tapestry of memories t...

The phenomenally popular Book of Lists series has sold millions of copies from coast to coast, enthralling trivia aficionados with fascinating infobits about simply everything! Now the latest edition turns an evil eye toward the strange, the blood-curdling, and the macabre with spine-tingling fun facts from the dark side of entertainment. Chock-full of creepy information from the netherworlds of movies, TV, literature, video games, comic books, and graphic novels, The Book of ...

From the late 1940s onward, Wallace W. Abbey masterfully combined journalistic and artistic vision to transform everyday transportation moments into magical photographs. Abbey, a photographer, journalist, historian, and railroad industry executive, helped people from many different backgrounds understand and appreciate what was taken for granted: a world of locomotives, passenger trains, big-city terminals, small-town depots, and railroaders. During his lifetime he witnessed and photograph...