As an area of research that continues to develop, the study of linguistics worldwide presents the opportunity for the improvement of cross-cultural communication through education and research. Language educators are charged with the task of instructing students to effectively communicate across cultures in a multi-lingual world. The Handbook of Research on Teaching Methods in Language Translation and Interpretation presents an interdisciplinary approach to educational contexts across cult...

This book illuminates the fundamental principle and applications of probability-based multi-objective optimization for material selection systematically, in which a brand new concept of preferable probability and its assessment as well as other treatments are introduced by authors for the first time. Hybrids of the new approach with experimental design methodologies, such as response surface methodology, orthogonal experimental design, and uniform experimental design, are all performed; th...

The second edition of this book illuminates the fundamental principle and applications of probability-based multi-objective optimization for material selection in viewpoint of system theory, in which a brand new concept of preferable probability and its assessment as well as other treatments are introduced by authors for the first time. Hybrids of the new approach with experimental design methodologies (response surface methodology, orthogonal experimental design, and uniform experimental ...

This book provides a framework for computational researchers studying the basics of cancer through comparative analyses of omic data. It discusses how key cancer pathways can be analyzed and discovered to derive new insights into the disease and identifies diagnostic and prognostic markers for cancer. Chapters explain the basic cancer biology and how cancer develops, including the many potential survival routes. The examination of gene-expression patterns uncovers commonalities across mult...

This book constitutes the refereed proceedings of the First International Conference on Big Scientific Data Management, BigSDM 2018, held in Beijing, Greece, in November/December 2018.The 24 full papers presented together with 7 short papers were carefully reviewed and selected from 86 submissions. The topics involved application cases in the big scientific data management, paradigms for enhancing scientific discovery through big data, data management challenges posed by big scient...

China through the Camera Lens combines Chinese language learning with film analysis, offering a unique and comprehensive learning experience beyond traditional methods.The book consists of twelve chapters, each based on a carefully selected short film or video. Each chapter is divided into a presentation section and a practice section. The presentation includes short narratives illustrated with color screen shots, with vocabulary glossed alongside for easy reference. It al...

This book introduces readers to a workload-aware methodology for large-scale graph algorithm optimization in graph-computing systems, and proposes several optimization techniques that can enable these systems to handle advanced graph algorithms efficiently. More concretely, it proposes a workload-aware cost model to guide the development of high-performance algorithms. On the basis of the cost model, the book subsequently presents a system-level optimization resulting in a partition-aware ...

Written by experts that include originators of some key ideas, chapters in the Handbook of Multiple Testing cover multiple comparison problems big and small, with guidance toward error rate control and insights on how principles developed earlier can be applied to current and emerging problems. Some highlights of the coverages are as follows.Error rate control is useful for controlling the incorrect decision rate. Chapter 1 introduces Tukey's original multiple comparison e...

The 2006 Nobel Prize in Physiology or Medicine was awarded to Andrew Z. Fire and Craig C. Mello for their discovery of RNA interference (RNAi). RNAi is a biological process in which RNA molecules can silence (inhibit) or up- or down-regulate gene expression, typically by causing the destruction of specific messenger RNA (mRNA) molecules. This collection of articles begins with an introduction to RNAi, and proceeds to describe uses of this technology in various approaches to disease treatme...

The ultimate source of information on the design of new anticancer agents, emphasizing small molecules, this newest work covers recent notable successes resulting from the human genome and cancer genomics projects. These advances have provided information on targets involved in specific cancers that are leading to effective medicines for at least some of the common solid tumors. Unique sections explain the basic underlying principles of cancer drug development and provide a practical intro...

The Molecular Biology of Cancer, Stella Pelengaris & Michael KhanThis capturing, comprehensive text, extensively revised and updated for its second edition, provides a detailed overview of the molecular mechanisms underpinning the development of cancer and its treatment.“Bench to Bedside”: A key strength of this book that sets it apart from general cancer biology references is the interweaving of all aspects of cancer biology from the causes, development an...

This book discusses the emergence of a new class of genes with a specific anticancer activity. These genes, recently defined as “Anticancer Genes”, are reviewed in individual chapters on their mode of action, the specific cell death signals they induce, and the status of attempts to translate them into clinical application.Anticancer Genes provides an overview of this nascent field, its genesis, current state, and prospect. It discusses how Anticancer Genes might lead to t...