The first comprehensive overview of preprocessing, mining, and postprocessing of biological dataMolecular biology is undergoing exponential growth in both the volume and complexity of biological data-and knowledge discovery offers the capacity to automate complex search and data analysis tasks. This book presents a vast overview of the most recent developments on techniques and approaches in the field of biological knowledge discovery and data mining (KDD)-providin...

Introducing a handbook for gene regulatory network research using evolutionary computation, with applications for computer scientists, computational and system biologistsThis book is a step-by-step guideline for research in gene regulatory networks (GRN) using evolutionary computation (EC). The book is organized into four parts that deliver materials in a way equally attractive for a reader with training in computation or biology. Each of these sections, authored b...

This book represents the most comprehensive and up-to-date collection of information on the topic of computational molecular biology. Bringing the most recent research into the forefront of discussion, Algorithms in Computational Molecular Biology studies the most important and useful algorithms currently being used in the field, and provides related problems. It also succeeds where other titles have failed, in offering a wide range of information from the introductory fundamental...

Introduces readers to core algorithmic techniques for next-generation sequencing (NGS) data analysis and discusses a wide range of computational techniques and applicationsThis book provides an in-depth survey of some of the recent developments in NGS and discusses mathematical and computational challenges in various application areas of NGS technologies. The 18 chapters featured in this book have been authored by bioinformatics experts and represent the latest wor...

A look at the methods and algorithms used to predict protein structureA thorough knowledge of the function and structure of proteins is critical for the advancement of biology and the life sciences as well as the development of better drugs, higher-yield crops, and even synthetic bio-fuels. To that end, this reference sheds light on the methods used for protein structure prediction and reveals the key applications of modeled structures. This indispensable book cove...

This monograph on measurement error and misclassification covers a broad range of problems and emphasizes unique features in modeling and analyzing problems arising from medical research and epidemiological studies. Many measurement error and misclassification problems have been addressed in various fields over the years as well as with a wide spectrum of data, including event history data (such as survival data and recurrent event data), correlated data (such as longitudinal data and clus...

These verses are the intense songs that my awakened heart sang out while fully engaged in living. They are songs asking questions, songs seeking answers, songs expressing pain, songs celebrating love, songs of appreciation and gratitude, and songs on a quest to create harmony and reconciliation. However, while reaching for light, I recognized the importance also of shadow. For without either, the landscape of our lives becomes featureless, lacking texture and depth. So the songs always tel...

Born in 1926, Shin Sang-ok is recognized as one of the masters of Korean cinema. After graduating from Tokyo Art School, he debuted as a director with “The Evil Night” in 1952 and went on to direct more than 70 films in five decades. Highly-acclaimed retrospectives of his work were screened at the 6th Pusan International Film Festival and at the Museum of Modern Art in New York. Shin was awarded the 1st Daejong Film Awards’ Best Director prize for “Mother and a Guest in the Room of Master”...

In this case study of the Sino-Indian conflict between 1959 and 1962, the author explores the attitudes that shaped India's policy toward China and traces the network of misunderstandings that led to a war unwanted by both sides.

On January 1, 2010 numerous changes were enacted to the Rules of Civil Procedure (the “Rules”) that govern civil litigation in Ontario. Many of these rule changes are subject to interpretation by the Court. The full effect of the changes on personal injury litigation in Ontario will only become clear with the passage of time. Certainly the most pressing and important change for personal injury law clerks will be to ensure that all documents are filed on time for motions or applications and...

Likelihood serves as a unifying concept in both the theory and practice of statistical science. This is, in a sense, inevitable when probability models are used as a basis for inference. While the key ideas were set out in Fisher in 1922, and further developed throughout the 1930s and 40s, it was the ubiquity of the personal computer and the development of general-purpose software that made likelihood-based inference the method of choice in a wide variety of applications.This book ...

Written in a unique style, this book is a valuable resource for faculty, graduate students, and researchers in the communications and networking area whose work interfaces with optimization. It teaches you how various optimization methods can be applied to solve complex problems in wireless networks. Each chapter reviews a specific optimization method and then demonstrates how to apply the theory in practice through a detailed case study taken from state-of-the-art research. You will learn...