Big data, genomics, and quantitative approaches to network-based analysis are combining to advance the frontiers of medicine as never before. Network Medicine introduces this rapidly evolving field of medical research, which promises to revolutionize the diagnosis and treatment of human diseases. With contributions from leading experts that highlight the necessity of a team-based approach in network medicine, this definitive volume provides readers with a state-of-the-art synthesi...

What would you write if no one knew who you were?In the spirit of the demolition derby, where drivers take heedless risks with reckless abandon, welcome to the first convocation of the Secret Society of Demolition Writers. Here is a one-of-a-kind collection by famous authors writing anonymously–and dangerously. With the usual concerns about reputations and renown cast aside, these twelve daredevils have each contributed an extreme, no-holds-barred unsigned story, each shining as br...

This 230,000-word collection includes the first THREE books in the best-selling John Milton series, plus the introductory novella, and is nearly 1000 pages (230,000 words) of espionage, revenge, thrills and spills.Meet John MiltonHe considers himself an artisan. A craftsman. His trade is murder.Milton is the man the government sends after you when everything else has failed. Ruthless. Brilliant. Anonymous. Lethal. You wouldn't pick him out of a crow...

Fast-paced and intriguing, Mightier than the Sword is the fifth novel in international bestseller Jeffrey Archer’s the Clifton Chronicles. It moves towards the end of the 1960s, as the Cliftons and the Barringtons come up against sworn enemies and new foes . . .Following the explosion of an IRA bomb on board the Barrington’s flagship MV Buckingham, Emma Clifton must deal with the repercussions on her family’s shipping business. Meanwhile her old a...

New York Times and USA Today Bestselling Author DIANE CAPRI Does It Again! NEW Hunt for Jack Reacher book!For fans of John Grisham, Lee Child, Jack Reacher and Michael Connelly"Full of thrills and tension, but smart and human, too. Kim Otto is a great, great character—I love her." Lee Child, #1 World Wide Bestselling Author of Jack Reacher ThrillersJack Reacher: Friend or Enemy?It’s been a while since we first met ...

A picaresque novel of how one person's actions can have far-reaching—even global—consequences, from a #1 international bestselling author."A funny and completely implausible farce about a woman, a bomb and a man's frustrated ambition to overthrow the king of Sweden. . . . The rest of the world will chuckle all the way through it." — Kirkus Reviews (starred review)In a tiny shack in the largest tow...

"Consistently pulse-raising. . .an exhilarating ride. . .Personal wrests back the sheer gusto of the earlier novels; it's the best Reacher adventure in some considerable time." (Independent)Jack Reacher walks alone.Once a go-to hard man in the US military police, now he's a drifter of no fixed abode. But the army tracks him down. Because someone has taken a long-range shot at the French president.Only one man could ...

Five figures gather round a shallow grave. They had all taken turns to dig. An adult sized hole would have taken longer. An innocent life had been taken but the pact had been made. Their secrets would be buried, bound in blood…Years later, a headmistress is found strangled, the first in a spate of gruesome murders which shock the Black Country. But when human remains are discovered at a former children’s home, disturbing secrets are also unearthed.Detect...

A Jack Reacher short story, published exclusively as an ebook: now also available in the new Reacher short story collection, No Middle Name.The tiny town of Naismith has nothing going for it - except the start of a wilderness trail through Maine's ancient forests. But one day the trail is suddenly closed by county police.No reason is given. Rumours start - is there something in the woods that no one must see? That no one must even know about?Then Jac...

Ambitious and addictive, Only Time Will Tell is the first novel in Jeffrey Archer’s The Clifton Chronicles, beginning the epic tale of Harry Clifton, a working-class boy from the docks of Bristol.It is 1920, and against the backdrop of a world ravaged by conflict, Harry’s story begins with the words ‘I was told that my father was killed in the war’. Harry’s existence is defined by the death of his father and he seems destined to a life on the docks until a...

Rapid advances in high-throughput genome sequencing technologies foreshadow a near-future in which millions of individuals will gain affordable access to their complete genome sequence. This promises to offer unprecedented insights into the fundamental biological nature of ourselves and our species: where we came from, how we begin our lives, how we develop and grow, how we interact with our environment, how we get sick, how we get well, and how we age. Personal genomics is an essential co...

New insights into the evolution and nature of proteinsExploring several distinct approaches, this book describes the methods for comparing protein sequences and protein structures in order to identify homologous relationships and classify proteins and protein domains into evolutionary families. Readers will discover the common features as well as the key philosophical differences underlying the major protein classification systems, including Pfam, Panther, SCOP, and CATH. Moreover,...