Once upon a time in a land not so far away lived a crazy rabbit hole. A gripping drama based on a true story and riddled with dark humor, from the insightful pen of K.L. Johns.In a small town where everyone knows your name but not all your secrets, Bailey faces the echoes of a turbulent past. Returning to her childhood home after twenty years she sifts through her childhood memories as humorous yet profound interactions with different characters shape her journey. Each encounter, l...

A gripping drama based on a true story and riddled with dark humor, from the insightful pen of K.L. Johns.Running from burnout, disillusionment, and a sociopath, Bailey's plan was simple. Returning to her childhood island town after 20 years away, she longed for rest and comfort, but the universe had other plans. Forged through fire, Bailey emerges as a chosen scribe and messenger for the people.The story blends dark humor, small‑town eccentricity, and introspective drama. ...

A gripping drama based on a true story and riddled with dark humor, from the insightful pen of K.L. Johns.Running from burnout, disillusionment, and a sociopath, Bailey's plan was simple. Returning to her childhood island town after 20 years away, she longed for rest and comfort, but the universe had other plans. Forged through fire, Bailey emerges as a chosen scribe and messenger for the people.The story blends dark humor, small‑town eccentricity, and introspective drama. ...

Clinically-focussed, with easily accessible tables and chapter summaries suitable for clinicians and researchers, this comprehensive book provides a systematic, critical evaluation of the current literature. An updated clinical decision-making algorithm specifically tailored to the antiretroviral drugs is also provided. The identified interactions are interpreted in the context of known mechanisms derived from clinical, preclinical, and in vitro data. The clinical relevance of the...

There has been major growth in understanding immune suppression mechanisms and its relationship to cancer progression and therapy. This book highlights emerging new principles of immune suppression that drive cancer, and it offers radically new ideas about how therapy can be improved by attacking these principles. Following work that firmly establishes immune escape as an essential trait of cancer, recent studies have now defined specific mechanisms of tumor immune suppression. It also dem...

This issue of the Surgical Oncology Clinics of North America, Guest Edited by Dr. William G. Cance, is devoted to Translational Cancer Research for Surgeons. Translational Cancer research aims to move bench research to the bedside by applying basic science toward potential therapies. This issue will present the concepts of translational research and development of targeted therapeutics, and its implications for surgeons. It will show clinical applications for surgeons regarding sarcoma/GIS...

The current state of the science supporting new research in lysophospholipidsThe study of lysophospholipids exploded with the discovery of cell surface receptors on both lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P). Since then, thousands of original research reports-ranging from fundamental cell signaling to the physiology and pathophysiology of individual organ systems-have centered on lysophospholipids. This book draws together and analyzes the c...

The use of model organisms together with the power of genetics has profoundly affected our understanding of the physiology of one organ, the skeleton, in two distinct but complementary ways. This is the first translational reference to focus on these major conceptual advances in bone biology and their development in the clinic. Several advances have already been translated into therapies and others are being tested for diseases as different as osteoporosis, type-2 diabetes, and hypo-fertil...

This work will provide a historical perspective on tumor immunotherapy, discuss fundamental mechanisms of failed tumor rejection, look at passive strategies to boost anti-tumor immunity, as well as have an in-depth look at active strategies to boost anti-tumor immunity.

Targeted Therapy in Translational Cancer Research for the Translational Oncology series provides a comprehensive overview of recent developments in our understanding of tumor biology, elucidates the roles of targets and pathways involved in carcinogenesis, and describes current state-of-the-art anticancer therapy, as well as the most promising areas of translational research and targeted therapy.Introduces cutting-edge ‘bench to bedside and back’ breakthroug...

Autophagy in Health and Disease offers an overview of the latest research in autophagy with a translational emphasis. This publication takes scientific research in autophagy a step further and offers integrated content with advancements in autophagy from cell biology and biochemical research to clinical treatments. A necessary reference for the bookshelf of medical and scientific researchers and students, Autophagy in Health and Disease presents high quality, reputable information on autop...

This timely book, published just as cancer immunotherapy comes of age, summarizes the rationale, present status, and future perspective for cancer immunotherapy. Included are explanations of the constitution of the immune system and immunocheckpoints, the mechanism of antigen presentation and recognition, valuable modalities, clinical trials and guidance, personalization, and biomarkers, all of which are essential for understanding the success of cancer immunotherapy. This innovative thera...