Collaborative Genomics Projects: A Comprehensive Guide contains operational procedures, policy considerations, and the many lessons learned by The Cancer Genome Atlas Project. This book guides the reader through methods in patient sample acquisition, the establishment of data generation and analysis pipelines, data storage and dissemination, quality control, auditing, and reporting. This book is essential for those looking to set up or collaborate within a large-scale genomics research pro...

When the brain suffers an injury, the effects can be delayed and unpredictable. Cerebrospinal fluid can slowly build up, causing dangerously high levels of intracranial pressure (ICP), and the brain tissue can be displaced into adjacent compartments, resulting in cerebral herniation syndrome (CHS). Within the burgeoning field of neurocritical care, experts are just beginning to understand the nuanced, sometimes counterintuitive relationship between ICP and CHS.Written by leading re...

In this fully revised and expanded fourth edition of the essential reference for clinical research coordinators, Deborrah Norris provides expanded coverage of CRC duties and regulatory requirements, including new sections on investigator responsibilities, data clarification, and adverse event reporting. The books five appendices include a directory of CRC resources, updated forms and checklists, state regulatory requirements and contact information, conversion charts and tables, and a glos...

Ready to take your IT skills to the healthcare industry? This concise book provides a candid assessment of the US healthcare system as it ramps up its use of electronic health records (EHRs) and other forms of IT to comply with the government’s Meaningful Use requirements. It’s a tremendous opportunity for tens of thousands of IT professionals, but it’s also a huge challenge: the program requires a complete makeover of archaic records systems, workflows, and other practices now in place.

The definitive guide to the use of mechanical ventilation in critically ill patients – now in full color and updated to reflect the latest advancesPrinciples & Practice of Mechanical Ventilation, 3e provides comprehensive, authoritative coverage of all the clinical, pharmacological, and technical issues surrounding the use of mechanical ventilation.Editor Martin J. Tobin – past editor-in-chief of the American Journal of Respiratory and Critical...

A must-have guide for any professional in the drug manufacturing industryThe Good Clinical Practice (GCP) audit is a tedious but necessary exercise that assures that all parties do their job properly and in compliance with the applicable FDA code. Clinical Trials Audit Preparation demystifies the audit process for all parties involved, including clinical research sponsors, clinical investigators, and institutional review boards.This book provides a...

The aims and scope of the second edition are unchanged from the first edition. The major market is in health informatics education. The three part format, which covers principles of health interoperability, HL7 and interchange formats, and SNOMED CT and clinical terminology, works well. In the US, The ONC (Office of the National Coordinator for Health Information Technology) has estimated that the HITECH stimulus will create more than 50,000 new jobs for health informatics professionals, w...

The cornerstone text on the theory and practice of regional anesthesia and pain managementPresented in full color, this classic covers the theory and practice of regional anesthesia in its entirety, providing practitioners and students with both the physiologic principles and specific, state-of-the-art patient-management protocols and techniques.Recognized leaders in the specialty have filled this richly illustrated volume with authoritative, completely pra...

Computational biology drives discovery through its use of high-throughput informatics approaches. This book provides a road map of the current drug development process and how computational biology approaches play a critical role across the entire drug discovery pipeline. Through the use of previously unpublished, real-life case studies the impact of a range of computational approaches are discussed at various phases of the pipeline. Additionally, a focus section provides innovative visual...

Over the years, medical informatics has matured into a true scientific discipline. Fundamental and applied aspects are now taught in various fields of health, including medicine, dentistry, pharmacy, nursing and public health. Medical informatics is also often included in the curricula of many other disciplines, including the life sciences, engineering and economics.Medical informatics is a complex and rapidly changing discipline. Relatively few books have been published on the sub...

Delirium, stupor and coma are common clinical states that confront clinicians in almost every medical specialty. With appropriate diagnosis and treatment, coma can often be treated successfully. Conversely, delay in diagnosis and treatment may be lethal. This monograph provides an update on the clinical approach that was laid out in the previous 3 editions. It describes an approach for the physician at the bedside to diagnose and treat alterations of consciousness, based on pathophysiologi...

This Brief defines competitive intelligence (CI) as a tool for making investment decisions within the pharmaceutical industry. It provides an overview of processes that the regulatory affairs professional must take into account when evaluating data impacting product-based risk evaluations. These apply particularly to evaluations that focus on outputs such as regulatory approval, or the commercial impact of product labeling on the sales forecast over a limited timeframe. The Brief also prov...