Based on decades of research centered on the earliest known fluted-point producing groups in the North American midcontinent, Early Paleoindians in the Upper Midcontinent of North America: Lithic Procurement, Settlement Mobility, and Social Interaction brings together a broad array of case studies from the United States and Canada that offers fresh perspectives on how early populations utilized the land and its resources, how and when they settled in particular locations, and how ...

The covalent conjugation of potent cytotoxic agents to monoclonal antibodies, known as antibody-drug conjugates (ADCs) is a powerful approach in the field of targeted treatment of cancer. Clearly, both monoclonal antibody and cytotoxic payload are crucial elements in determining the clinical value of an ADC and have receive ample attention. However, the structural element connecting the two –the chemical linker– also plays an essential role in mode-of-action, efficacy, pharmacokinetics and...