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Engineering (R0) Bogserier

1 - 12 af 12 resultater
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  • High-Resolution Profiling of Protein-RNA Interactions

    af Mathias Munschauer ...
    Serier serie Engineering (R0)
    The work reported in this book represents an excellent example of how creative experimentation and technology development, complemented by computational data analysis, can yield important insights that further our understanding of biological entities from a systems perspective. The book describes how the study of a single RNA-binding protein and its interaction sites led to the development of the ... Læs mere

    840,29 kr.

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  • Polypharmacology in Drug Discovery

    Redigeret af Jens-Uwe Peters ...
    An essential outline of the main facets of polypharmacology in drug discovery researchExtending drug discovery opportunities beyond the "one drug, one target" philosophy, a polypharmacological approach to the treatment of complex diseases is emerging as a hot topic in both industry and academic research. Polypharmacology in Drug Discovery presents an overview of the various facets of ... Læs mere

    1.070,99 kr.

  • Epigenetics in Cancer

    af Wiley ...
    Serier serie Life Science Research Fundamentals
    Epigenetics is the study of heritable changes in gene expression or cellular phenotype, caused by mechanisms other than changes in the DNA sequence. Examples include DNA methylation and histone modification. These changes may remain through cell divisions and multiple generations. Epigenetic differences among individuals may account for some of the differences between monozygotic (identical) twins ... Læs mere

    269,24 kr.

  • Metabolomics in Practice

    Successful Strategies to Generate and Analyze Metabolic Data

    Redigeret af Wolfram Weckwerth, Michael Lämmerhofer ...
    Unlike other handbooks in this emerging field, this guide focuses on the challenges and critical parameters in running a metabolomics study, including such often-neglected issues as sample preparation, choice of separation and detection method, recording and evaluating data as well as method validation. By systematically covering the entire workflow, from sample preparation to data processing, the ... Læs mere

    889,11 kr.

  • Protein Surface Recognition

    Approaches for Drug Discovery

    Redigeret af Ernest Giralt, Mark Peczuh, Xavier Salvatella ...
    A new perspective on the design of molecular therapeutics is emerging. This new strategy emphasizes the rational complementation of functionality along extended patches of a protein surface with the aim of inhibiting protein/protein interactions. The successful development of compounds able to inhibit these interactions offers a unique chance to selectively intervene in a large number of key ... Læs mere

    1.198,99 kr.

  • MicroRNAs as Tools in Biopharmaceutical Production

    Redigeret af Niall Barron ...
    Serier serie Biomedical and Life Sciences (R0)
    Focused manuscript on the potential use/role of miRNAs in bioprocessing, specifically the production of complex proteins in mammalian cells. With that in mind I propose a draft list of topics/chapters along the following lines: Intro on CHO/bioprocessing/engineering challenges to set scene, Genomic organization, biogenesis and mode of action, Identifying miRNA targets: Computational prediction, ... Læs mere

    756,36 kr.

  • Long Non Coding RNA Biology

    Redigeret af M.R.S. Rao ...
    Serier serie Biomedical and Life Sciences (R0)
    This contributed volume offers a comprehensive and detailed overview of the various aspects of long non-coding RNAs and discusses their emerging significance. Written by leading experts in the field, it motivates young researchers around the globe, and offers graduate and postgraduate students fascinating insights into genes and their regulation in eukaryotes and higher organisms. ... Læs mere

    1.008,49 kr.

  • Regulatory RNAs

    Basics, Methods and Applications

    Redigeret af Bibekanand Mallick, Zhumur Ghosh ...
    Serier serie Biomedical and Life Sciences (R0)
    Recent progress in high-throughput technologies and genome wide transcriptome studies have lead to a significant scientific milestone of discovering non-coding RNAs (ncRNAs) which spans through a major portion of the genome. These RNAs most often act as riboregulators, and actively participate in the regulation of important cellular functions at the transcriptional and/or post-transcriptional ... Læs mere

    1.867,43 kr.

  • Molecular Neuropharmacology

    Strategies and Methods

    Redigeret af Arne Schousboe, Hans Bräuner-Osborne ...
    Serier serie Medicine (R0)
    A powerful collection of readily reproducible cutting-edge techniques for characterizing the ligand or substrate binding of neurotransmitter receptors and transporters. The procedures cover interdisciplinary interactions for monoamine transporters, amino acid transporters, ionotropic receptors, metabotropic glutamate receptors, GABA receptors, and other G protein-coupled receptors. By illuminating ... Læs mere

    1.176,49 kr.

  • Protein-Protein Interactions in Drug Discovery

    af Raimund Mannhold, Hugo Kubinyi, Gerd Folkers ...
    Serier Bog 56 - Methods & Principles in Medicinal Chemistry
    Treating protein-protein interactions as a novel and highly promising class of drug targets, this volume introduces the underlying strategies step by step, from the biology of PPIs to biophysical and computational methods for their investigation.The main part of the book describes examples of protein targets for which small molecule modulators have been developed, covering such diverse fields as ... Læs mere

    1.347,49 kr.

  • GPCRs: From Deorphanization to Lead Structure Identification

    Redigeret af H. Bourne, Richard Horuk, J. Kuhnke, H. Michel ...
    Serier serie Biomedical and Life Sciences (R0)
    Based on the international workshop GPCRs: From Deorphanisation to Lead Structure Identification, held in Berlin in May 2006, the book highlights the following topics: Structure of GPCRs, Design of GPCR Ligands, GPCR Signalling, Deorphanization and Assay Development. All chapters are written by leading experts in the field, discussing the most recent state of the art. They give insight into the ... Læs mere

    755,61 kr.

  • Protein Kinase CK2

    af Lorenzo A. Pinna ...
    Serier Bog 6 - The Wiley-IUBMB Series on Biochemistry and Molecular Biology
    Protein kinases play a critical role in cellular processes that impact overall organismal health and function. Of the kinases that collectively make up the Human Kinome, CK2 has garnered special attention because of its significant role in the generation of the human phosphoproteome. The role CK2 plays in the development of cancer and other disease has also made it of significant interest for its ... Læs mere

    1.630,24 kr.