This book provides a comprehensive overview of the latest research in the role of non-neuronal cells - astrocytes, oligodendrocytes, endothelial cells, pericytes, microglia, and other immune cells in ischemic brain injury and long-term recovery. In these cases, neurodegeneration and brain repair are controlled in a sophisticated system, incorporating interactions between different cell types and cellular systems. Also explored are the therapeutic strategies that target non-neuronal respons...

Recent research has revealed the importance of immunological mechanisms and inflammation in delaying damage and/or promoting repair after an acute injury to the central nervous system. This book provides a comprehensive and up-to-date overview of the role of immunological mechanisms and therapies for treating acute neurological injuries such as cerebral ischemia, hemorrhage, and brain and spinal cord trauma. In several sections, the contributing authors provide a review of immunological me...

This book is mainly focused on the climate change in Southeast Asia and its adjacent regions. It summarizes results from recent scientific research based on observational analysis, data diagnosis, theoretical analysis, and model simulations. The book covers the following research areas: (1) characteristics and mechanisms of spring–summer atmospheric circulation systems, (2) ocean-atmosphere-land interaction and climate variability, (3) climate effect of the Tibetan Plateau, (4) attribution...

Fully revised for the fifth edition, this outstanding reference on bone marrow transplantation is an essential, field-leading resource.Extensive coverage of the field, from the scientific basis for stem-cell transplantation to the future direction of researchCombines the knowledge and expertise of over 170 international specialists across 106 chaptersIncludes new chapters addressing basic science experiments in stem-cell biology, immunolog...

Hepatocellular cancer is the fifth most common cancer, with 600,000 new cases reported each year worldwide. Additionally, exciting changes in the science of HCC in the last four years have turned the practice of diagnosing and treating the disease upside down. In Hepatocellular Carcinoma: Diagnosis and Treatment, Second Edition, the leading experts in the field of HCC thoroughly update and expand upon the critically acclaimed first edition with all the latest developments in the diagnosis ...

To ensure the best possible clinical outcomes for arthritis patients, it is essential that they be seen early and treated appropriately at the earliest opportunity. Early therapy has proven much more effective than that given late. This issue of Rheumatic Disease Clinics of North America brings the rheumatologist up to date on the latest treatments and interventions in evolving arthritis and established early arthritis. Topics covered include early rheumatoid arthritis, psoriatic arthritis...

Educational advancement in the field of psoriatic arthritis which this book will provide is consistent with GRAPPA’s aims and objectives leading to a productive synergy. GRAPPA (Group for Research and Assessment of Psoriasis and Psoriatic Arthritis), is recognized world wide as the leading international society for the study and promotion of awareness of psoriatic arthritis. GRAPPA is an association of leading rheumatologists, dermatologists, representatives of patient service leagues and ...

The Autoimmune Diseases, Sixth Edition, emphasizes the "3 P's" of 21st Century medicine: precision, prediction and prevention. Topics cover the modern systems approach to biology that involves large amounts of personalized, ongoing physiologic data ("omics") coupled with advanced methods of analysis, new tests of genetic engineering, such as CRISPR, auto inflammatory diseases, autoimmune responses to tumor immunotherapy, and information on normal immune response and disorders. Each of the ...

Edited by Drs. Jack Cush and Kathryn Dao, this issue of Rheumatic Disease Clinics of North America addresses one of the most significant issues facing the rheumatologist today––drug safety in a changing world where rheumatoid arthritis (RA) severity is less, patients are being identified and treated at a very early stage, and prevention is on the horizon. Topics covered include: communicating the risk of side effects, urate-lowering therapies, biphosphonates, biologics, malignancy risks, a...

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product.The world's most highly regarded reference text on the mechanisms and clinical management of blood diseasesA Doody's Core Title for 2020!Edition after edition, Williams Hematology has guided generations o...

Handbook of Clinical Neurology: Neuro-Oncology, Part I summarizes the present state of scientific and clinical knowledge in the field of neuro-oncology, including information related to diagnostic techniques such as imaging, along with immunology, molecular biology, and clinical aspects of tumors. Management and new therapeutic strategies for tumors, including gene therapy and molecularly targeted treatments, are also covered. Divided into eight sections encompassing 61 chapters, the book ...

Mammalian Toll-like receptors (TLRs) were first identified in 1997 based on their homology with Drosophila Toll, which mediates innate immunity in the fly. In recent years, the number of studies describing TLR expression and function in the nervous system has been increasing steadily and expanding beyond their traditional roles in infectious diseases to neurodegenerative disorders and injury. Interest in the field serves as the impetus for this volume in the Current Topics in Microbiology ...