The Ugly American, novel by William J. Lederer and Eugene Burdick, published in 1958. A fictionalized account of Americans working in Southeast Asia, the book was notable chiefly for exposing many of the deficiencies in U.S. foreign-aid policy and for causing a furor in government circles. Eventually the uproar led to a congressional review of foreign aid. Although some of the novelís characters are committed to the local people, many others are incompetent and out of touch with and ill-in...

Contents E.I. Christensen and R. Nielsen: Role of Megalin and Cubilin in Renal Physiology and Pathophysiology G. Zifarelli and M. Pusch: CLC Chloride Channels and Transporters: A Biophysical and Physiological Perspective S.F.J. van de Graaf, R.J.M. Bindels and J.G.J. Hoenderop: Physiology of Epithelial Ca2 and Mg2+ Transport

F. Schweda and A. Kurtz: Regulation of Renin Release by Local and Systemic FactorsM. Krauss and V. Haucke: Shaping Membranes for EndocytosisB.M. Jockusch and P.L. Graumann: The Long Journey: Actin on the Road to Pro- and Eukaryotic CellsB. Colsoul, R. Vennekens and B. Nilius: Transient Receptor Potential (TRP) Cation Channels in Pancreatic ß cells

Contents E.I. Christensen and R. Nielsen: Role of Megalin and Cubilin in Renal Physiology and Pathophysiology G. Zifarelli and M. Pusch: CLC Chloride Channels and Transporters: A Biophysical and Physiological Perspective S.F.J. van de Graaf, R.J.M. Bindels and J.G.J. Hoenderop: Physiology of Epithelial Ca2 and Mg2+ Transport

Contents Philip C. Sharpe, Rosemary S. Harrison, and David P. Fairlie: Amyloid Peptides and Proteins in Review. - Marilena Kampa, Artemissia-Phoebe Nifli, George Notas, Elias Castanas: Polyphenols and Cancer Cell Growth. - Michal Janitz: Assigning Functions to Genes – The Main Challenge of the Post-Genomic Era. - Brigittte M. Jockusch, Kai Murk and Martin Rothkegel: The Profile of Profilins.

Most of the antibiotics now in use have been discovered more or less by chance, and their mechanisms of action have only been elucidated after their discovery. To meet the medical need for next-generation antibiotics, a more rational approach to antibiotic development is clearly needed.Opening with a general introduction about antimicrobial drugs, their targets and the problem of antibiotic resistance, this reference systematically covers currently known antibiotic classes, their m...

Glioblastoma is the most malignant brain tumor that still remains incurable. It is such a deadly disease that patients do not survive more than a few months after diagnosis. Our understanding of the histopathology and molecular mechanisms of formation of glioblastoma is rapidly advancing so as to provide us clues for devising rational therapeutic strategies for treatment of this malignancy. It is important that we continue to improve our knowledge about the pathogenesis of this devastating...

This is a third edition of the popular book, which presents an overview of the most recent findings in the biology of neutrophils. These cells are critically important for protection against bacterial and viral infections and have been recently demonstrated to be a major contributor to tumor associated immune suppression. In addition, neutrophils represent a unique model for studying fundamental questions of cellular biochemistry and molecular biology. This monograph provides a detailed de...

Fundamentals of Osteoporosis offers a concise yet comprehensive source of all the latest basic research related to osteoporosis in one reference work. Experts from all areas of osteoporosis research expose readers to genomic and proteomic analysis, and histopathology and imaging, as well cellular and molecular mechanisms relevant to assay development and drug discovery. - Presents a concise yet comprehensive source of all the latest basic research related to osteoporosis in one reference w...

Principles of Bone Biology provides the most comprehensive, authoritative reference on the study of bone biology and related diseases. It is the essential resource for anyone involved in the study of bone biology. Bone research in recent years has generated enormous attention, mainly because of the broad public health implications of osteoporosis and related bone disorders. - Provides a "one-stop" shop. There is no need to search through many research journals or books to glean the informa...

This book gives a comprehensive insight into platelet biogenesis, platelet signal transduction, involvement of platelets in disease, the use of diverse animal models for platelet research and future perspectives in regard to platelet production and gene therapy. Being written by international experts, the book is a concise state-of-the art work in the field of platelet biogenesis, biology and research. It represents an indispensable tool for research scientists in biomedicine, vascular bio...

Current Advances in Osteosarcoma edited by Dr. Eugenie S. Kleinerman summarizes molecular and genetic characteristics, new therapeutic ideas, and biological characteristics that have been uncovered in the past 10 years. Osteosarcoma is an aggressive malignant neoplasm and it is also the most common histological form of bone cancer. It accounts for approximately 56% of new bone tumors, making it the most primary malignant bone tumor in children and adolescents. The lungs are the most common...