This book is intended as a communication platform to bridge the cultural, conceptual, and technological gap among the key systems biology disciplines of biology, mathematics, and information technology. To support this goal, contributors were asked to adopts an approach that appeals to audiences from different backgrounds.

Complex systems modeling and simulation approaches are being adopted in a growing number of sectors, including finance, economics, biology, astronomy, and many more. Technologies ranging from distributed computing to specialized hardware are explored and developed to address the computational requirements arising in complex systems simulations.The aim of this book is to present a representative overview of contemporary large-scale computing technologies in the context of complex sy...

Networked Graphics equips programmers and designers with a thorough grounding in the techniques used to create truly network-enabled computer graphics and games. Written for graphics/game/VE developers and students, it assumes no prior knowledge of networking.The text offers a broad view of what types of different architectural patterns can be found in current systems, and readers will learn the tradeoffs in achieving system requirements on the Internet. It explains the foundations of netw...

This book describes the key concepts, principles and implementation options for creating high-assurance cloud computing solutions. The guide starts with a broad technical overview and basic introduction to cloud computing, looking at the overall architecture of the cloud, client systems, the modern Internet and cloud computing data centers. It then delves into the core challenges of showing how reliability and fault-tolerance can be abstracted, how the resulting questions can be solved, an...

This first systematic treatment of the concept and practice of scaffold hopping shows the tricks of the trade and provides invaluable guidance for the reader's own projects.The first section serves as an introduction to the topic by describing the concept of scaffolds, their discovery, diversity and representation, and their importance for finding new chemical entities. The following part describes the most common tools and methods for scaffold hopping, whether topological, shape-b...

GPU-based Parallel Implementation of Swarm Intelligence Algorithms combines and covers two emerging areas attracting increased attention and applications: graphics processing units (GPUs) for general-purpose computing (GPGPU) and swarm intelligence. This book not only presents GPGPU in adequate detail, but also includes guidance on the appropriate implementation of swarm intelligence algorithms on the GPU platform. GPU-based implementations of several typical swarm intelligence algorithms ...

Mathematics of Bioinformatics: Theory, Methods, and Applications provides a comprehensive format for connecting and integrating information derived from mathematical methods and applying it to the understanding of biological sequences, structures, and networks. Each chapter is divided into a number of sections based on the bioinformatics topics and related mathematical theory and methods. Each topic of the section is comprised of the following three parts: an introduction to the biological...

The world is awash with digital data from social networks, blogs, business, science and engineering. Data-intensive computing facilitates understanding of complex problems that must process massive amounts of data. Through the development of new classes of software, algorithms and hardware, data-intensive applications can provide timely and meaningful analytical results in response to exponentially growing data complexity and associated analysis requirements. This emerging area brings many...

Cloud Computing: Theory and Practice provides students and IT professionals with an in-depth analysis of the cloud from the ground up. Beginning with a discussion of parallel computing and architectures and distributed systems, the book turns to contemporary cloud infrastructures, how they are being deployed at leading companies such as Amazon, Google and Apple, and how they can be applied in fields such as healthcare, banking and science. The volume also examines how to successfully deplo...

Presenting the concept and design and implementation of configurable intelligent optimization algorithms in manufacturing systems, this book provides a new configuration method to optimize manufacturing processes. It provides a comprehensive elaboration of basic intelligent optimization algorithms, and demonstrates how their improvement, hybridization and parallelization can be applied to manufacturing. Furthermore, various applications of these intelligent optimization algorithms are exem...

Frontiers in Computational Chemistry, originally published by Bentham and now distributed by Elsevier, presents the latest research findings and methods in the diverse field of computational chemistry, focusing on molecular modeling techniques used in drug discovery and the drug development process. This includes computer-aided molecular design, drug discovery and development, lead generation, lead optimization, database management, computer and molecular graphics, and the development of n...

Essential for all biology and biomathematics courses, this textbook provides students with a fresh perspective of quantitative techniques in biology in a field where virtually any advance in the life sciences requires a sophisticated mathematical approach. An Invitation to Biomathematics, expertly written by a team of experienced educators, offers students a solid understanding of solving biological problems with mathematical applications. This text succeeds in enabling students to truly e...