In this brief the authors introduce a series of recently developed bio-based solvents including cyclopentyl methyl ether (CPME), γ-valerolactone (GVL), 2-methyl tetrahydrofuran (2-MeTHF), propylene carbonate (PC), and cyrene. Traditional organic solvents used for organic synthesis (such as benzene, ether, chloroform) have a series drawbacks on toxicity, environmental impact, and safely related issues. In addition, the fossil fuel-derived organic solvents are not sustainable. Therefore the ...

This book emphasizes the atom economy aspect of multicomponent reactions. It describes how this methodology has been applied to several named reactions. Among the “twelve principles of green chemistry”, atom economy addresses ‘synthetic efficiency’. A multicomponent reaction can be defined as an energy, cost, and time efficient method for organic synthesis. Instead of making one or two bonds in a chemical transformation, multicomponent reactions generate several chemical bonds in a single ...