The authoritative guide for Data Monitoring Committees—fully revised and updatedThe number of clinical trials sponsored by government agencies and pharmaceutical companies has grown in recent years, prompting an increased need for interim monitoring of data on safety and efficacy. Data Monitoring Committees (DMCs) are an essential component of many clinical trials, safeguarding trial participants and protecting the credibility and validity of the study. Data Mo...

This vivid, deeply moving book begins in London in 1620 as Pilgrim representatives sign a contract to purchase the freighter Mayflower. We accompany them on their harrowing voyage across the Atlantic, through the rigors of the first New England winter and the threat of Indian attack as they desperately search for the home they eventually find at Plymouth. Once there, they must continue the struggle against brutal weather and disease. With masterly skill, New York Times bestselling historia...

"The best spy novel written about the American Revolution." - John Gardner. Freezing winds cut across the snowbound landscape. George Washington's rebel troops shiver in their huts, bellies empty, and carrying resentment sharper than their swords. Across the frozen Hudson, the British carouse in the brothels of New York, while their leaders plot to break the deadlock that threatens to bleed the British Empire dry. Thomas Flemings's Revolutionary War masterpiece, Dreams of Glory, takes plac...

New York Times bestselling historian Thomas Fleming brings his extraordinary biographical talents to bear upon Benjamin Franklin, perhaps the least understood of America's revolutionary giants. For this reappraisal, Fleming concentrates on the mature Franklin, the man who lived nearly thirty years beyond the point where he ended his famous Autobiography. The poor boy, the miserly young printer, has become a decidedly more complex and cultured man. In scene after vivid scene, Fleming shows ...

In Verdicts of History, New York Times bestselling historian Thomas Fleming highlights six courtroom dramas that changed the future of America. From unexpected verdicts, like the acquittal won by John Adams when he defended British soldiers charged with the Boston Massacre in 1770 to stirred passions when abolitionist John Brown was convicted of murder - a precedent to the Civil War - to the breakthrough in racial relations when Clarence Darrow won a stunning "not guilty" verdict for black...

"A superb retelling of the story of Valley Forge and its aftermath, demonstrating that reality is far more compelling than myth." - Gordon S. Wood. The defining moments of the American Revolution did not occur on the battlefield or at the diplomatic table, writes New York Times bestselling author Thomas Fleming, but at Valley Forge. Fleming transports us to December 1777. While the British army lives in luxury in conquered Philadelphia, Washington's troops huddle in the barracks of Valley ...

New York Times bestselling author Thomas Fleming tells a haunting love story set against of the more perplexing and least explored chapters of World War II. In Berlin, Berthe von Hoffman dreams of an angel in the depths, embracing her husband's submarine and remembers Kristallnacht, when Hitler declared all-out war on the Jews. The stench of evil in that memory draws her to the headquarters of Admiral Wilhelm Canaris, enigmatic head of the German secret service and guiding spirit of the Sc...

Liberty! brings to life one of the most important and compelling stories in America's history: the struggle for independence and the birth of the nation. New York Times bestselling historian Thomas Fleming's gripping narrative captures the high drama of the revolutionary war years and the unyielding courage and political genius of the men and women who imagined a new set of political possibilities for humankind - laying the foundation for the identity and character of the American people i...

Choosing the most important moments in the long history of the American presidency is difficult. But here, New York Times bestselling historian Thomas Fleming vividly recreates many of those hours of crisis - from George Washington's fight for peace and the night Abraham Lincoln was almost shot to Ronald Reagan's plea to "tear down this wall" and George W. Bush on September 11, 2001, "the day that changed everything."

In this swift, insightful book, New York Times bestselling author Thomas Fleming brings vividly to life the remarkable youth of Thomas Jefferson, one of America's greatest presidents. Here are all of Jefferson's early triumphs and tragedies - from his inspired design and construction of Monticello and election as Virginia's second governor to his achievement as the author of the Declaration of Independence and the devastating loss of his wife.

"Written with skill and suspense, it is an inspiring story that Americans can read with pride." - Chicago Tribune. Here, from New York Times bestselling author Thomas Fleming, is the story of that June day in 1775 that made the American Revolution inevitable. Bunker Hill brings alive the stories of the men on both sides who fought on these steep slopes in the blazing heat of June and dispels the myths and distortions which have long clouded the battle. It shows how closely and tragically i...

Few writers have told the story of the American Revolution with more grace, clarity, or emotional power than New York Times bestselling historian Thomas Fleming. Here, collected for the first time and posthumously, are Fleming's favorite works. He takes us back to the days of the founders, detailing the surprising facts of American life in 1776, including its resemblance to today. He tells the seldom-told tale of the Loyalists, supporters of England who acted on their political convictions...