This issue of Immunology and Allergy Clinics provides a comprehensive review of the current state of biomarkers and their role in the asthma diagnostic and therapeutic algorithm.Since the last issue on Biomarkers, which published in 2007, significant research directly targeted at biomarker development and clinical trials with new biologics, using biomarkers such as exhaled nitric oxide, sputum and tissue eosinophilia as endpoints, has occurred.

This issue of Immunology and Allergy Clinics of North America, guest edited by Dr. Rohit Katial, is devoted to Severe Asthma. Articles in this issue include: Epidemiology and Pulmonary Physiology of Severe Asthma; Linkage and Genetic Associations in Severe Asthma; Asthma COPD Overlap Syndrome (ACOS); Biomarkers in Severe Asthma; Imaging in Severe Asthma; Eosinophilic Phenotype; Neutrophilic and Pauci-immune Phenotypes; Role of Sleep Apnea and Gastroesophageal Reflux Disease in Severe Asthm...

The Yearbook compiles the most recent developments in experimental andclinical research and practice in one comprehensive reference book. Thechapters are written by well recognized experts in the field of intensive care and emergency medicine. It is addressed to everyone involved in internal medicine, anesthesia, surgery, pediatrics, intensive care and emergency medicine.

Cancer imposes daunting effects on the nervous systemBrain cancer is one of the most devastating diagnoses a physician can deliver. Cancer of the nervous system can take many different forms. Treatment is specific to the type of malignancy, its location in the nervous system and, increasingly, its molecular characteristics. The challenges manifest further when management choices need to be made, and multidisciplinary approaches are required. Additional complexities...

Guest edited by Jonathan Kay, this issue of Rheumatic Disease Clinics will cover the latest research and evidence surrounding the diagnosis, treatment and management of rarely seen rheumatic diseases.

- Six new chapters — Biliary and Pancreatic Obstruction, Depression and Cognitive Dysfunction, Dyspnea and Airway Obstruction, GI Obstruction, Heart Failure, and Spiritual Distress — keep you up to date with the latest advances in oncology nursing. - Evidence-based rationales in the nursing interventions help you apply the latest research findings to actual practice. - Each chapter includes a new section on pathophysiology to help you understand the physiologic processes associated with ea...

This six-volume series has been compiled to introduce current, up-to-date concepts concerning the diagnosis, evaluation, and management rationale of the various conditions that otorhinolaryngologists encounter in their clinics, hospitals, and operating rooms. It has been our goal to keep this information complete yet concise. -- Milind V. Kirtane and Chris E. de Souza, Series EditorsA Multidisciplinary Approach to Head and Neck Neoplasms is a comp...

The Yearbook compiles the most recent developments in experimental and clinical research and practice in one comprehensive reference book. The chapters are written by well recognized experts in the field of intensive care and emergency medicine. It is addressed to everyone involved in internal medicine, anesthesia, surgery, pediatrics, intensive care and emergency medicine.

The field encompassed by rheumatology has evolved rapidly over the last decade to include multiple immune-modulating and biologic medications, new classification criteria, significant updates on bone metabolism, and completely new paradigms of treatment based on groundbreaking studies published within the last 5 years. Although much has been adopted as standard of care based on new data, most textbooks do not reflect these practice changes.Rheumatology Board Review highlig...

Fluid, electrolyte, and acid-base disorders are central to the day-to-day practice of almost all areas of patient-centered medicine – both medical and surgical. Virtually every aspect of these disorders has experienced major developments in recent years.Core Concepts in the Disorders of Fluid, Electrolytes and Acid-Base Balance encompasses these new findings in comprehensive reviews of both pathophysiology and clinical management. In addition, this volume offers clinical e...

A host of new technologies, techniques, and medical regimens have been introduced over the past 30 years for the diagnosis, management, and prevention of urinary calculi. These range from novel imaging procedures and medical expulsive therapy to interventional treatment options. The contemporary urologist should be familiar with and adept at implementing these new concepts and techniques. Clinical Management of Urolithiasis will serve as a practical guide to every clinically relev...

Pancreatitis: medical and surgical management provides gastroenterologists and GI surgeons, both fully qualified and in training, with a focused, evidence-based approach to the most exciting developments in the diagnosis and clinical management of pancreatitis.Focusing mainly on the rapidly changing and innovative medical and surgical strategies to manage the disease, new surgical procedures such as endoscopic biliary intervention and minimally invasive necrosectomy to exc...