This comprehensive volume explores human genetic engineering its pre-clinical and clinical applications, current developments, and as treatment for hereditary diseases. It presents and evaluates the most recent advances in the understanding of mammalian host DNA repair mechanisms, such as double-strand break induced gene targeting and mutagenesis, the development of zinc-finger nucleases, genome editing for neuromuscular diseases, phase integrases, triplex forming oligonucleotides and pept...

Written by leading IT security educators, this fully updated Lab Manual supplements Principles of Computer Security: CompTIA Security+ and Beyond, Second Edition Principles of Computer Security Lab Manual, Second Edition, contains more than 30 labs that challenge you to solve real-world problems with key concepts. Clear, measurable lab objectives map to CompTIA Security+ certification exam objectives, ensuring clear correspondence to Principles of Computer Securit...

Cancer therapeutics include an ever-increasing array of tools at the disposal of clinicians in their treatment of this disease. However, cancer is a tough opponent in this battle, and current treatments, which typically include radiotherapy, chemotherapy and surgery, are not often enough to rid the patient of his or her cancer. Cancer cells can become resistant to the treatments directed at them, and overcoming this drug resistance is an important research focus. Additionally, increasing d...

A fully updated edition of the world’s bestselling computer security book Hacking Exposed 7: Network Security Secrets and Solutions is filled with all-new information on today's most devastating attacks and proven countermeasures. The book covers: advanced persistent threats; infrastructure hacks; industrial automation and embedded devices; wireless security; the new SCADA protocol hacks; Microsoft Windows Server 2010; Web 2.0; Ubuntu Linux; hardware; Cisco; RFID; malware; ...

This textbook provides a fresh, comprehensive and accessible introduction to the rapidly expanding field of molecular pharmacology. Adopting a drug target-based, rather than the traditional organ/system based, approach this innovative guide reflects the current advances and research trend towards molecular based drug design, derived from a detailed understanding of chemical responses in the body. Drugs are then tailored to fit a treatment profile, rather than the traditional method of ‘tri...

A helpful guide on all things CiscoDo you wish that the complex topics of routers, switches, and networking could be presented in a simple, understandable presentation? With Cisco Networking All-in-One For Dummies, they are! This expansive reference is packed with all the information you need to learn to use Cisco routers and switches to develop and manage secure Cisco networks. This straightforward-by-fun guide offers expansive coverage of Cisco and break...

This book comprehensively covers the mechanisms of action and inhibitor design for HIV-1 integrase. It serves as a resource for scientists facing challenging drug design issues and researchers in antiviral drug discovery. Despite numerous review articles and isolated book chapters dealing with HIV-1 integrase, there has not been a single source for those working to devise anti-AIDS drugs against this promising target. But this book fills that gap and offers a valuable introduction to the f...

Finally, a stand-alone, all-inclusive textbook on yeast biology.Based on the feedback resulting from his highly successful monograph, Horst Feldmann has totally rewritten he contents to produce a comprehensive, student-friendly textbook on the topic. The scope has been widened, with almost double the content so as to include all aspects of yeast biology, from genetics via cell biology right up to biotechnology applications. The cell and molecular biology sections have been vastly ex...

A plain-English guide to the market-leading virtualization and cloud computing technologyWith virtualization, a single server can host dozens or hundreds of virtual machines running a variety of operating systems, and even hook them together in a virtual network or cloud infrastructure. This practical guide shows you how to create a virtual system using the VMware VSphere environment. You'll find all the information you need to understand, design, and deploy one—wi...

The post-genomic era has brought new challenges and opportunities in all fields of the biology. In this context, several genome engineering technologies have emerged that will help deciphering genes function by as well as improve gene therapy strategies. Genomic modifications such as knock-in, knock-out, knock-down, sequence replacement or modification can today be routinely performed. However, in front of this large palette of methodologies scientists may experience difficulties to gather...

Written in Packts Beginners Guide format, you can easily grasp the concepts and understand the techniques to perform wireless attacks in your lab. Every new attack is described in the form of a lab exercise with rich illustrations of all the steps associated. You will practically implement various attacks as you go along. If you are an IT security professional or a security consultant who wants to get started with wireless testing with Backtrack, or just plain inquisitive about wireless se...

Every time a cell divides, a copy of its genomic DNA has to be faithfully copied to generate new genomic DNA for the daughter cells. The process of DNA replication needs to be precisely regulated to ensure that replication of the genome is complete and accurate, but that re-replication does not occur. Errors in DNA replication can lead to genome instability and cancer. The process of replication initiation is of paramount importance, because once the cell is committed to replicate DNA, it ...