How to identify optimal phase II trial designsProviding a practical guide containing the information needed to make crucial decisions regarding phase II trial designs, A Practical Guide to Designing Phase II Trials in Oncology sets forth specific points for consideration between the statistician and clinician when designing a phase II trial, including issues such as how the treatment works, choice of outcome measure and randomization, and considering both ...

Examines how the president balances the competing demands of leading his political party and leading the nation.Throughout their time in office, American presidents are often forced to choose between leading the nation and leading their party. In an earlier time when the major parties were less polarized, this leadership dilemma, while challenging, was not nearly as vexing as it is today. American presidents now find themselves with little room to maneuver, compell...

Feisty women spanning six centuries ...The twenty-three stories in this collection depict ordinary women—from the 1470s to the 1970s—who meet life’s challenges with fierce determination.An unhappy housewife in 1950s California gathers the courage to escape an abusive marriage. When local men are shipped off to WWI, a young Yorkshire woman joins others to keep a munitions factory at peak operation. As her land and way of life are threatened, a nineteenth century Chi...

This book provides a comprehensive outline of the major parent training programs for parents of children with intellectual or developmental disabilities (IDD), including Autism Spectrum Disorder.Parents or primary caregivers spend the most time with a child, and training them in behaviour management and intervention strategies is critical to improving a child's behaviour, to helping them to learn new skills, and to reduce parental stress. Authored by eminent specialists in the fiel...

This book is the first ethnography of the little-known world of clozapine clinics in Australia and the United Kingdom. Anthropologist Julia Brown engages with the narratives of people living in extreme health circumstances to challenge some of the assumptions made about clozapine treatment and to explore what it means to be diagnosed with ‘treatment-resistant schizophrenia.’Clozapine is a gold standard but controversial treatment for psychosis that requires lifelong monitoring to r...

Izzy Finds Her Brave is a heartwarming story about Izzy, a gentle German Shepherd who loves her family but struggles with being shy. When an unexpected challenge puts her in the spotlight, Izzy must find the courage to step outside her comfort zone. With the support and encouragement from her best friends, Sadie and Benji, Izzy discovers confidence, courage, and the brave heart that was insider her all alone.Perfect for your readers ages 3-8, this charming adventur...

This audiobook is narrated by a digital voice.General Anatomy and Physiology is a comprehensive textbook designed for community and technical college students, examining the basic concepts of human anatomy and physiology as they relate to health sciences. Using a body systems approach, the book emphasizes the interrelationships between structure and function at both the gross and microscopic levels of organization. It covers essential topics such as anatomical terminology, cellular...

The city, with its manifold distractions and violence, its invitation to intoxication and dream, had long served to represent the experience of modernity in works of art at the time John Schlesinger made his acclaimed urban documentary ‘Terminus’ in 1961. To be a reader of the city was to be a reader of modern life, and Schlesinger was a discriminating, at times relentless, reader of the city throughout his career, especially in his three greatest films, ‘Midnight Cowboy’, ‘Sunday Bloody S...

The great historical and economic transformations of the late twentieth-century city are vividly reflected in John Schlesinger’s oeuvre. In films of the early sixties ‘A Kind of Loving’ and ‘Billy Liar’, the city was imagined as industrial and residential, with the characters confronting life on the local and familial level. In ‘Darling’, ‘Midnight Cowboy’ and ‘Sunday Bloody Sunday’, films made from 1965 to 1971, the city had become cosmopolitan, ruled over by international finance and riv...

The great historical and economic transformations of the late twentieth-century city are vividly reflected in John Schlesinger’s oeuvre. In films of the early sixties ‘A Kind of Loving’ and ‘Billy Liar’, the city was imagined as industrial and residential, with the characters confronting life on the local and familial level. In ‘Darling’, ‘Midnight Cowboy’ and ‘Sunday Bloody Sunday’, films made from 1965 to 1971, the city had become cosmopolitan, ruled over by international finance and riv...

These provocative essays offer a bold vision of the benefits of reading that challenges contemporary trends, reintroducing neglected works of fiction and memoir.For readers curious to learn about both novels that have been neglected and ideas that are becoming endangered – because they challenge contemporary tastes and values – Reclamations provides fresh readings of a curated selection of books from the 19th, 20th, and 21st centuries. Reading a wide range...

**Contains Trigger & Content Warning 18+**AMAZON BEST SELLERS#1 in Erotic Suspense#1 in Erotic Thrillers#1 in Erotic Horror#2 in KidnappingSet in Hastings in the UK.In the serene setting of Lucy's neighbourhood, an eerie presence looms right next door.George, the seemingly ordinary nei...