Inherited skeletal disorders have a fascination for many medical and surgical disciplines. For the geneticist there is interest in the study of families and their inheritance of lesions. The paediatrician is concerned because most of the disorders present in childhood as a problem in clinical differential diagnosis. The radiologist is interested because of the manifest, multiple and curious bone changes that provide a challenge in diagnosis and classification. The orthopaedic surgeon is in...

Addressing clients’ questions and concerns about the role of genetics in mental illness.As we learn more about how our biology and genes can play into the development of a mental health disorder, patients and their families are increasingly seeking answers to tough questions about common risk factors, the likelihood of recurrence, the need for genetic testing, and implications for future generations.A practical, go-to resource for all mental health clinicia...

Written by leading surgeons with expertise in performing osteotomies around the knee, this book is an essential reference for the current techniques in joint-preserving knee surgery. The book opens with a thorough discussion of physiology, pathophysiology, clinical evaluation, and imaging. It then describes the indications and basic principles of treatment and provides a detailed planning algorithm for high-tibial osteotomy. Separate chapters cover various clinical applications, addressing...

This book identifies and analyzes the genetic basis of bone disorders in humans and demonstrates the utility of mouse models in furthering the knowledge of mechanisms and evaluations of treatments. The book is aimed at all students of bone biology and genetics, and with this in mind, it includes general introductory chapters on genetics and bone biology and more specific disease-orientated chapters, which comprehensively summarize the clinical, genetic, molecular genetic, animal model, fun...

In this book, leading international experts showcase the latest advances in research into Dupuytren disease and its clinical management. The coverage spans all relevant specialties, including cell biology, biomechanics, genomics, surgery, pharmacotherapy, and radiotherapy. The opening sections address epidemiology, cellular and extracellular events, and genetics. Treatment by means of collagenase injection, percutaneous needle fasciotomy, and other surgical and minimally invasive approache...

Joint hypermobility, joint laxity or "double-jointedness" is no longer regarded as just a quaint clinical entity, but has gained recognition as a feature common to a heterogeneous group of generalized hereditary connective tissue disorders. This monograph examines the scientific basis, clinical features and treatment of this syndrome. The second edition has been thoroughly updated, with new contributions to cover in depth three areas in which new scientific advances have been made: biochem...

Equip yourself with all the guidance you need to diagnose, stabilize and provide the initial management of MSK emergencies as effectively as possible. Optimize patient's disposition ranging from emergency department discharge to the operating room. A leading orthopaedic trauma surgeon and a respected emergency physician bridge the gap between these specialties to help you give these patients the best chances of favorable outcomes. - Address emergency orthopaedics - both acute trauma and ur...

The field of rheumatology has undergone numerous exciting advances in recent years, especially the development of biological drugs with novel targets, made possible by rapid advances in the basic science of musculoskeletal diseases together with improved imaging techniques. This thoroughly revised fourth edition of the Oxford Textbook of Rheumatology reflects the changing face of the specialty and the many recent advances in the science, treatment, and understanding of rheumatic diseases. ...

In few areas of medicine is progress more spectacular than in the field of prenatal diagnosis. New clinical techniques such as chorion villus sampling, detailed ultrasound scanning and cordocentesis are being evaluated by obstetricians, and refinement of biochemical testing is widening the scope of maternal serum screening. In the laboratory, dramatic advances in molecular biology are occurring: families at risk of genetic disease can be investigated with gene probes, and preimplantation d...

Gene therapy for inflammatory diseases is a new , burgeoning field of medicine. Edited by the undisputed pioneers of this area of research, this volume is the first devoted to its topic. It contains thirteen chapters, each written by leaders in their respective fields, that summarize the state of the art in developing novel, gene based treatments for inflammatory diseases. As well as providing an introduction to the basic concepts of gene therapy and the use of naked DNA approaches, the bo...

This fifth volume in the AOSpine Masters Series presents a detailed analysis of the essential aspects of managing the most common cervical spine injuries. World-renowned cervical spine experts discuss anatomy, biomechanics, patient evaluation, and critical steps in the decision-making process for the treatment of these complex injuries. Chapters include: Anatomy of the Cervical Spine, Nonoperative Management of Cervical Spine Trauma, and Subaxial Cervical Spine Injuries.Key Feature...

Developmental genetic studies of the spine and linkage and family-based association studies have led to recent advances in understanding the genetic etiology of idiopathic, neuromuscular, and congenital forms of scoliosis. The book is written by leaders in genetic and developmental research on scoliosis and developmental studies of the spine.