Randomised Response-Adaptive Designs in Clinical Trials presents methods for the randomised allocation of treatments to patients in sequential clinical trials. Emphasizing the practical application of clinical trial designs, the book is designed for medical and applied statisticians, clinicians, and statisticians in training. After introducing clin

This book collects the proceedings of the 10th Workshop on Model-Oriented Design and Analysis (mODa). A model-oriented view on the design of experiments, which is the unifying theme of all mODa meetings, assumes some knowledge of the form of the data-generating process and naturally leads to the so-called optimum experimental design. Its theory and practice have since become important in many scientific and technological fields, ranging from optimal designs for dynamic models in pharmacolo...

This volume contains pioneering contributions to both the theory and practice of optimal experimental design. Topics include the optimality of designs in linear and nonlinear models, as well as designs for correlated observations and for sequential experimentation. There is an emphasis on applications to medicine, in particular, to the design of clinical trials. Scientists from Europe, the US, Asia, Australia and Africa contributed to this volume of papers from the 11th Workshop on Model O...

This open access book presents robust statistical methods and procedures through the monitoring approach, with an emphasis on applications to linear regression. Illustrating the theory, it explores both large and small-sample properties. The performance of the forward search and of the monitoring of static robust estimators for regression data are illuminated through numerous data analyses using MATLAB and R.The book describes the results of many years’ work of the authors in the d...

The field's leading text, now completely updated.Modeling dynamical systems — theory, methodology, and applications.Lennart Ljung's System Identification: Theory for the User is a complete, coherent description of the theory, methodology, and practice of System Identification. This completely revised Second Edition introduces subspace methods, methods that utilize frequency domain data, and general non-linear black box methods, including neural networks and neuro-f...

The positive reciprocal pairwise comparison matrix (PCM) is one of the key components which is used to quantify the qualitative and/or intangible attributes into measurable quantities. This book examines six understudied issues of PCM, i.e. consistency test, inconsistent data identification and adjustment, data collection, missing or uncertain data estimation, and sensitivity analysis of rank reversal. The maximum eigenvalue threshold method is proposed as the new consistency index for the...

Markov decision process (MDP) models are widely used for modeling sequential decision-making problems that arise in engineering, economics, computer science, and the social sciences. Many real-world problems modeled by MDPs have huge state and/or action spaces, giving an opening to the curse of dimensionality and so making practical solution of the resulting models intractable. In other cases, the system of interest is too complex to allow explicit specification of some of the MDP model pa...

The first part of this book is devoted to methods seeking relevant dimensions of data. The variables thus obtained provide a synthetic description which often results in a graphical representation of the data. After a general presentation of the discriminating analysis, the second part is devoted to clustering methods which constitute another method, often complementary to the methods described in the first part, to synthesize and to analyze the data. The book concludes by examining the li...

This book offers a useful combination of probabilistic and statistical tools for analyzing nonlinear time series. Key features of the book include a study of the extremal behavior of nonlinear time series and a comprehensive list of nonlinear models that address different aspects of nonlinearity. Several inferential methods, including quasi likelihood methods, sequential Markov Chain Monte Carlo Methods and particle filters, are also included so as to provide an overall view of the availab...

Methods for estimating sparse and large covariance matricesCovariance and correlation matrices play fundamental roles in every aspect of the analysis of multivariate data collected from a variety of fields including business and economics, health care, engineering, and environmental and physical sciences. High-Dimensional Covariance Estimation provides accessible and comprehensive coverage of the classical and modern approaches for estimating covariance ma...

This book provides clear instructions to researchers on how to apply Structural Equation Models (SEMs) for analyzing the inter relationships between observed and latent variables.Basic and Advanced Bayesian Structural Equation Model**ing introduces basic and advanced SEMs for analyzing various kinds of complex data, such as ordered and unordered categorical data, multilevel data, mixture data, longitudinal data, highly non-normal data, as well as some of t...

Provides an in-depth and even treatment of the three pillars of computational intelligence and how they relate to one anotherThis book covers the three fundamental topics that form the basis of computational intelligence: neural networks, fuzzy systems, and evolutionary computation. The text focuses on inspiration, design, theory, and practical aspects of implementing procedures to solve real-world problems. While other books in the three fields that comprise compu...