An essential outline of the main facets of polypharmacology in drug discovery researchExtending drug discovery opportunities beyond the "one drug, one target" philosophy, a polypharmacological approach to the treatment of complex diseases is emerging as a hot topic in both industry and academic research. Polypharmacology in Drug Discovery presents an overview of the various facets of polypharmacology and how it can be applied as an innovative concept for developing medicines for tr...

Practical guide to navigate problems involved with promiscuous ligands and multi-target drug discovery, supported by case studies and real examplesPolypharmacology covers the two-sided nature of polypharmacology: its relevance for adverse drug effects, as well as its benefit for certain therapeutic drug classes in effectively treating complex diseases like psychosis and cancer. The book provides practical guidelines and advice to help readers design drugs ...

The Challenge of Tradition emphasizes the tension between Theodor Adorno's critique of tradition as being incompatible with capitalist modernity and his understanding of the need for maintaining aesthetic and cultural connections with the past. Placing the concept of tradition in the larger context of late modernity, Peter Uwe Hohendahl argues that Adorno redeems tradition even as he critiques it.Beginning his analysis with Adorno's 1966 e...

A discussion of Theodor Adorno's Aesthetic Theory is bound to look significantly different today than it would have looked when the book was first published in 1970, or when it first appeared in English translation in the 1980s. In The Fleeting Promise of Art, Peter Uwe Hohendahl reexamines Aesthetic Theory along with Adorno's other writings on aesthetics in light of the unexpected return of the aesthetic to today's cultural debates.Is Adorno's aesthetic theory sti...

Building a National Literature boldly takes issue with traditional literary criticism for its failure to explain how literature as a body is created and shaped by institutional forces. Peter Uwe Hohendahl approaches literary history by focusing on the material and ideological structures that determine the canonical status of writers and works. He examines important elements in the making of a national literature, including the political and litera...

Since his death, the writings of Carl Schmitt (1888–1985) have been debated, cited, and adopted by political and legal thinkers on both the left and right with increasing frequency, though not without controversy given Schmitt's unwavering support for National Socialism before and during World War II. In Perilous Futures, Peter Uwe Hohendahl calls for critical scrutiny of Schmitt's later writings, the work in which Schmitt wrestles with concerns that retain presen...

A Berlin Republic brings together writings on the new, united Germany by one of their most original and trenchant commentators, J&uumlrgen Habermas. Among other topics, he addresses the consequences of German history, the challenges and perils of the post-Wall era, and Germany's place in contemporary Europe.Here, as in his earlier The Past as Future, Habermas emerges as an inspired analyst of contemporary German political and intellectual life. He repeatedly criti...

Brought to you by Penguin.The story of the phenomenon that is Kraftwerk, and how they revolutionised our cultural landscape'We are not artists nor musicians. We are workers.' Ignoring nearly all rock traditions, experimenting in near-total secrecy in their Düsseldorf studio, Kraftwerk fused sound and technology, graphic design and performance, modernist Bauhaus aesthetics and Rhineland industrialisation - even human and machine - to change ...

This book provides an introduction to investment appraisal and presents a range of methods and models, some of which are not widely known, or at least not well covered by other textbooks. Each approach is thoroughly described, evaluated and illustrated using examples, with its assumptions and limitations analyzed in terms of their implications for investment decision-making practice. Investment decisions are of vital importance to all companies. Getting these decisions right is crucial but...

Reappraisals is a provocative account of the development of modern critical theory in Germany and the United States. Focusing on the period since World War II, Peter Uwe Hohendahl explores key debates on the function of critical theory, illuminating the diverse positions and alliances among the participants. Bringing together six essays, as well as new introductory and concluding chapters, Hohendahl interprets and subjects to critical scrutiny man...

The Practical Guide to Optimizing Product Value through Better Teamwork with Scrum“Professional Scrum is hard, not because the ideas are hard, but because it requires persistence, focus, and dedication to not let the day-to-day realities get in the way. In this book, Peter, Uwe, and Kurt have provided a collection of materials to help the Scrum Team deliver value and feel happy doing it.”--Dave West, CEO and Product Owner, Scrum.org...

This well-established book on injury biomechanics has been extensively revised and expanded for this new edition. It now includes a fundamental treatment of the mechanics at a cellular level, written by the new coauthor Prof. Barclay Morrison III from Columbia University. Furthermore, considerably more attention is paid to computer modeling, and in particular modeling the human body.The book addresses a wide range of topics in injury biomechanics, including anatomy, injury classifi...