An essential outline of the main facets of polypharmacology in drug discovery researchExtending drug discovery opportunities beyond the "one drug, one target" philosophy, a polypharmacological approach to the treatment of complex diseases is emerging as a hot topic in both industry and academic research. Polypharmacology in Drug Discovery presents an overview of the various facets of polypharmacology and how it can be applied as an innovative concept for developing medicines for tr...

Practical guide to navigate problems involved with promiscuous ligands and multi-target drug discovery, supported by case studies and real examplesPolypharmacology covers the two-sided nature of polypharmacology: its relevance for adverse drug effects, as well as its benefit for certain therapeutic drug classes in effectively treating complex diseases like psychosis and cancer. The book provides practical guidelines and advice to help readers design drugs ...

The Challenge of Tradition emphasizes the tension between Theodor Adorno's critique of tradition as being incompatible with capitalist modernity and his understanding of the need for maintaining aesthetic and cultural connections with the past. Placing the concept of tradition in the larger context of late modernity, Peter Uwe Hohendahl argues that Adorno redeems tradition even as he critiques it.Beginning his analysis with Adorno's 1966 e...

A Berlin Republic brings together writings on the new, united Germany by one of their most original and trenchant commentators, J&uumlrgen Habermas. Among other topics, he addresses the consequences of German history, the challenges and perils of the post-Wall era, and Germany's place in contemporary Europe.Here, as in his earlier The Past as Future, Habermas emerges as an inspired analyst of contemporary German political and intellectual life. He repeatedly criti...

Reappraisals is a provocative account of the development of modern critical theory in Germany and the United States. Focusing on the period since World War II, Peter Uwe Hohendahl explores key debates on the function of critical theory, illuminating the diverse positions and alliances among the participants. Bringing together six essays, as well as new introductory and concluding chapters, Hohendahl interprets and subjects to critical scrutiny man...

Brought to you by Penguin.The story of the phenomenon that is Kraftwerk, and how they revolutionised our cultural landscape'We are not artists nor musicians. We are workers.' Ignoring nearly all rock traditions, experimenting in near-total secrecy in their Düsseldorf studio, Kraftwerk fused sound and technology, graphic design and performance, modernist Bauhaus aesthetics and Rhineland industrialisation - even human and machine - to change ...

This well-established book on injury biomechanics has been extensively revised and expanded for this new edition. It now includes a fundamental treatment of the mechanics at a cellular level, written by the new coauthor Prof. Barclay Morrison III from Columbia University. Furthermore, considerably more attention is paid to computer modeling, and in particular modeling the human body.The book addresses a wide range of topics in injury biomechanics, including anatomy, injury classifi...

The aging and migration megatrends and their impact on spatial – regional and local – labor market performance is the core theme of this book, and thus together define its scope and focus. The contributions provide an overview of key aging and migration issues in various countries together with analyses of their varied impacts on regional labor markets. Systematic database research and related empirical analyses are used to map out the complex and dynamic nature of these trends, while cutt...

An important aim behind the restructuring of Germany’s and Europe’s electricity systems is to reduce the environmental burden, especially with respect to greenhouse gas emissions, of the current systems. Emissions must be brought down to a level that is sustainable in the long run and consistent with greenhouse gas emission reduction goals. Meeting these goals will require a system (as best as current knowledge suggests) that will be able to cope simultaneously with the fundamental demands...

This book presents a collection of results from the interdisciplinary research project “ELLI” published by researchers at RWTH Aachen University, the TU Dortmund and Ruhr-Universität Bochum between 2011 and 2016. All contributions showcase essential research results, concepts and innovative teaching methods to improve engineering education. Further, they focus on a variety of areas, including virtual and remote teaching and learning environments, student mobility, support throughout the st...

A discussion of Theodor Adorno's Aesthetic Theory is bound to look significantly different today than it would have looked when the book was first published in 1970, or when it first appeared in English translation in the 1980s. In The Fleeting Promise of Art, Peter Uwe Hohendahl reexamines Aesthetic Theory along with Adorno's other writings on aesthetics in light of the unexpected return of the aesthetic to today's cultural debates.Is Adorno's aesthetic theory sti...

Since his death, the writings of Carl Schmitt (1888–1985) have been debated, cited, and adopted by political and legal thinkers on both the left and right with increasing frequency, though not without controversy given Schmitt's unwavering support for National Socialism before and during World War II. In Perilous Futures, Peter Uwe Hohendahl calls for critical scrutiny of Schmitt's later writings, the work in which Schmitt wrestles with concerns that retain presen...