HMG-CoA reductase inhibitors (statins) are established drugs for the treatment of hypercholesterolemia. Furthermore, they induce regression of vascular atherosclerosis as well as reduction of cardiovascular-related morbidity and death in patients with and without coronary artery disease. This book deals with statins which have substantially altered the approach to therapy of atherosclerosis and its sequelae. Emphasis is placed on the scientific background to the discoveries and the develop...

Gerd B. Achenbach’s Philosophical Praxis: Origin, Relations, and Legacy, translated by Michael Picard, offers unique insights into the compelling origin and development of what has been called a renaissance of philosophy: a storied trove of thought steeped in tradition, character, and experience, and redeployed in the service of understanding the individual life. Throughout this book, the author explores Philosophical Praxis not only through the tumultuous history of philosophy, b...

Following an opening chapter by the late Susumu Ohno on paralogues of sex-determining genes, the five best-studied genes essential for early mammalian gonadal development are portrayed in detail: SF-1 and WT1 and their roles in early events in gonadal development, SRY and SOX9 in testis determination, and the anti-testis gene DAX-1. Subsequent chapters look at the roles of these genes in sex determination in marsupial mammals, birds, reptiles, amphibians and fish, and review the different ...

Medical Risk Prediction Models: With Ties to Machine Learning is a hands-on book for clinicians, epidemiologists, and professional statisticians who need to make or evaluate a statistical prediction model based on data. The subject of the book is the patient’s individualized probability of a medical event within a given time horizon. Gerds and Kattan describe the mathematical details of making and evaluating a statistical prediction model in a highly pedagogical manner whi...

The world's coastlines represent a myriad of dynamic and constantly changing environments. Heavily settled and intensely used areas, they are of enormous importance to humans and understanding how they are shaped and change is crucial to our future.Introduction to Coastal Processes and Geomorphologybegins by discussing coastal systems and shows how these systems link to the processes examined in detail throughout the book. These include the morphodynamic paradigm, tides, waves and ...

The Moment of Liberation in Western Europe: Power Struggles & Rebellions, 1943–1948, regards the final two years of World War II and the immediate post-liberation period as a moment in twentieth century history when the shape and contours of postwar Western Europe appeared highly uncertain and various alternatives and conflicting visions were up for grabs. After close to six years of total war, Nazi terror, and brutal occupation policies, a growing number of Europeans were no long...

This book discusses the development of the Rosenbrock—Wanner methods from the origins of the idea to current research with the stable and efficient numerical solution and differential-algebraic systems of equations, still in focus. The reader gets a comprehensive insight into the classical methods as well as into the development and properties of novel W-methods, two-step and exponential Rosenbrock methods. In addition, descriptive applications from the fields of water and hydrogen network...

Twenty thousand years ago our planet was an icehouse. Temperatures were down six degrees; ice sheets kilometres thick buried much of Europe and North America and sea levels were 130m lower. The following 15 millennia saw an astonishing transformation as our planet metamorphosed into the temperate world upon which our civilisation has grown and thrived. One of the most dynamic periods in Earth history saw rocketing temperatures melt the great ice sheets like butter on a hot summer's day; fe...

In this wide-ranging Very Short Introduction to climate, Mark Maslin considers all aspects of the global climate system, exploring and explaining the different components that control climate on Earth. He considers the processes that allow energy to reach the Earth and how it is redistributed around the planet by the ocean-atmosphere system; the relationship and differences between climate and the weather; how climate has affected life on Earth and human settlements; and the cycli...

What were the landscapes of the past like? What will landscapes look like in the future? Landscapes are all around us, but most of us know very little about how they have developed, what goes on in them, and how they react to changing climates, tectonics and human activities. Examining what landscape is, and how we use a range of ideas and techniques to study it, Andrew Goudie and Heather Viles demonstrate how geomorphologists have built on classic methods pioneered by some great 19th cent...

Tectonic geomorphology is the study of the interplay between tectonic and surface processes that shape the landscape in regions of active deformation and at time scales ranging from days to millions of years. Over the past decade, recent advances in the quantification of both rates and the physical basis of tectonic and surface processes have underpinned an explosion of new research in the field of tectonic geomorphology. Modern tectonic geomorphology is an exceptionally integrative field ...

A revised and updated comprehensive examination of the supervolcanic eruption of Toba in Sumatra, Indonesia over 75,000 years ago, and how it changed human genetic history by causing a population bottleneck, written by best-selling author Marie D. Jones and her father, the late geophysicist Dr. John M. Savino, Ph.D. The book describes what a supervolcano is, how they form, where they are located across the globe, and which ones may be ready to erupt. Will Yellowstone be next? Features a fi...