Essential Statistics for the Pharmaceutical Sciences is targeted at all those involved in research in pharmacology, pharmacy or other areas of pharmaceutical science; everybody from undergraduate project students to experienced researchers should find the material they need.This book will guide all those who are not specialist statisticians in using sound statistical principles throughout the whole journey of a research project - designing the work, selecting appropriate s...

A hands-on guide to using statistics in health research, from planning, through analysis, and on to reportingA Practical Approach to Using Statistics in Health Research offers an easy to use, step-by-step guide for using statistics in health research. The authors use their experience of statistics and health research to explain how statistics fit in to all stages of the research process. They explain how to determine necessary sample sizes, interpret wheth...

There is something about the number 3.The Ancient Greeks believed 3 was the perfect number, and in China 3 has always been a lucky number, and they know a thing or two.Most religions also have 3 this and 3 that and, of course, in these more modern times, three’s a crowd may be too many, except when it’s a ménage à trois. It seems good things usually come in threes. Whatever history and culture says WE think 3, a hat-trick of stories, is a great number to explore themes and ...

Four more delightful tales from one of the most entertaining storytellers of all time. Though writing in the thirteenth century, Chaucer’s wit and observation comes down undiminished through the ages, especially in this accessible modern verse translation. The stories vary considerably from the uproarious Wife of Bath’s Tale, promoting the power of women to the sober account of patient Griselda in the Clerk’s Tale.

Now in its seventh edition, this reputable textbook is an ideal introduction to the study of human movement and an excellent reference encouraging and directing further study. For the first time there is a chapter dedicated to measuring and understanding physical activity, recognising the importance of this area to many health and sports professionals. More time is spent explaining the basic principles of biomechanics and the way they can be used to improve practice, including tissue mecha...

There is something about the number 3.The Ancient Greeks believed 3 was the perfect number, and in China 3 has always been a lucky number, and they know a thing or two.Most religions also have 3 this and 3 that and, of course, in these more modern times, three’s a crowd may be too many, except when it’s a ménage à trois. It seems good things usually come in threes.Whatever history and culture says WE think 3, a hat-trick of stories, is a great number to explore them...

In her thesis, Sara Bobone outlines spectroscopic studies of antimicrobial peptides (AMPs) which are promising lead compounds for drugs used to fight multidrug resistant bacteria. Bobone shows that AMPs interact with liposomes and she clarifies the structure of pores formed by one of these molecules. These results help us to understand how AMPs are selective for bacterial membranes and how their activity can be finely tuned by modifying their sequence. Findings which solve several conundru...

This volume addresses neuronal pain mechanisms at the peripheral, spinal and supraspinal level which are thought to significantly contribute to pain and which may be the basis for the development of new treatment principles. Chapters on nociceptive mechanisms in the peripheral nociceptive system address the concept of hyperalgesic priming, the role of voltage-gated sodium channels in different inflammatory and neuropathic pain states, the hyperalgesic effects of NGF in different tissues an...

Building on the success of the 14 previous editions, this remarkable reference has been extensively reorganized and expanded and now comprises almost 1,500 individual drug articles providing the most complete coverage of adverse reactions and interactions found anywhere. Each article contains detailed and authoritative information about the adverse effects of each drug, with comprehensive references to the primary literature making this a must have for any academic or medical library, phar...

Cancer Drug Design and Discovery, Second Edition is an important reference on the underlying principles for the design and subsequent development of new anticancer small molecule agents. New chapters have been added to this edition on areas of particular interest and therapeutic promise, including cancer genomics and personalized medicine, DNA-targeted agents and more. This book includes several sections on the basic and applied science of cancer drug discovery and features those drugs tha...

This book describes the techniques, strategies, and drugs that have been demonstrated by well-documented randomized trials to influence survival in the perioperative setting. It takes into consideration all types of adult surgery and will be relevant to the evaluation of any patient undergoing an operative procedure. Each chapter focuses on a specific procedure, device, or drug. The scope is accordingly wide, with coverage of topics as diverse as chlorhexidine oral rinse, clonidine therapy...

Protein kinase C (PKC), a family of serine-threonine kinases, rocketed to the forefront of the cancer research field in the early 1980’s with its identification as an effector of phorbol esters, natural products with tumor promoting activity. Phorbol esters had long been of interest to the cancer research field due to early studies in the mouse skin carcinogenesis model, which showed that prolonged topical application of phorbol esters promoted the formation of skin tumors on mice previous...