Winner of the 2023 PROSE award in Biomedicine and Neuroscience! Research in the field of senescence has boomed recently due to the gradual realization that senescent cells are associated with a significant number of diseases. The genetic or pharmacological elimination of senescent cells can cause widespread benefits and improves outcomes for most of those diseases. Cellular Senescence in Diseases presents an updated review of the role of cellular senescence in multiple pathologies. Focus i...

- El síndrome metabólico es uno de los retos más intrigantes y fascinantes de la medicina contemporánea. Se trata de una patología en la que confluyen problemas de distintas áreas de la medicina: diferentes grados de hipertensión, acumulación de grasa, insulinoresistencia, estados protrombótico y proinflamatorio, todos juntos en la misma persona. Esta concurrencia de factores hace que la persona tenga un riesgo mucho mayor de sufrir enfermedad cardiovascular o diabetes mellitus tipo 2, que...

Obesity is the second volume in a four-title series, along with Type 2 Diabetes Mellitus (T2D), Arterial Hypertension, and Atherogenic dyslipidemia. It covers every major aspect of obesity from a multidisciplinary approach, thanks to collaborative efforts of a select team of international, world-reknowned experts. It offers updated information on a wide variety of topics, ranging from the general to the specific. These include the pathophysiology of obesity; the influence of social, demogr...

This book constitutes the thoroughly refereed revised selected papers of the 16th International Symposium on Trends in Functional Programming, TFP 2015, held in Sophia Antipolis, France, in June 2015. The 8 revised full papers included in this volume were carefully and selected from 26 submissions. TFP is an international forum for researchers with interests in all aspects of functional programming, taking a broad view of current and future trends in the area. It aspires to be a lively env...

Over the past years, a considerable amount of effort has been devoted, both in industry and academia, towards the development of basic technology as well as innovative applications for the Internet of Things. Adaptive Middleware for the Internet of Things introduces a scalable, interoperable and privacy-preserving approach to realize IoT applications and discusses abstractions and mechanisms at the middleware level that simplify the realization of services that can adapt autonomously to th...

Publisher's Note: This edition from 2017 is outdated and not compatible with TensorFlow 2.x or any of the most recent updates to Python libraries. A new edition completely updated and revised for 2020 with seven additional chapters that cover RNNs, AI and big data, fundamental use cases, chatbots, and more, is now available. Build real-world Artificial Intelligence applications with Python to intelligently interact with the world around you. Key FeaturesStep int...

Programming Language Pragmatics, Third Edition, is the most comprehensive programming language book available today. Taking the perspective that language design and implementation are tightly interconnected and that neither can be fully understood in isolation, this critically acclaimed and bestselling book has been thoroughly updated to cover the most recent developments in programming language design, inclouding Java 6 and 7, C++0X, C# 3.0, F#, Fortran 2003 and 2008, Ada 2005, and Scheme...

This is a comprehensive account of the semantics and the implementation of the whole Lisp family of languages, namely Lisp, Scheme and related dialects. It describes 11 interpreters and 2 compilers, including very recent techniques of interpretation and compilation. The book is in two parts. The first starts from a simple evaluation function and enriches it with multiple name spaces, continuations and side-effects with commented variants, while at the same time the language used to define ...

Information Modeling and Relational Databases, Second Edition, provides an introduction to ORM (Object-Role Modeling)and much more. In fact, it is the only book to go beyond introductory coverage and provide all of the in-depth instruction you need to transform knowledge from domain experts into a sound database design. This book is intended for anyone with a stake in the accuracy and efficacy of databases: systems analysts, information modelers, database designers and administrators, and ...

This textbook describes all phases of a compiler: lexical analysis, parsing, abstract syntax, semantic actions, intermediate representations, instruction selection via tree matching, dataflow analysis, graph-coloring register allocation, and runtime systems. It includes good coverage of current techniques in code generation and register allocation, as well as the compilation of functional and object-oriented languages, that is missing from most books. The most accepted and successful techn...

Software practitioners are rapidly discovering the immense value of Domain-Specific Languages (DSLs) in solving problems within clearly definable problem domains. Developers are applying DSLs to improve productivity and quality in a wide range of areas, such as finance, combat simulation, macro scripting, image generation, and more. But until now, there have been few practical resources that explain how DSLs work and how to construct them for optimal use.***Software Language Engine...

This textbook is intended for an introductory course on Compiler Design, suitable for use in an undergraduate programme in computer science or related fields.Introduction to Compiler Design presents techniques for making realistic, though non-optimizing compilers for simple programming languages using methods that are close to those used in "real" compilers, albeit slightly simplified in places for presentation purposes. All phases required for translating a high-level lan...