Sepsis and infection are the major enemies of the intensive care patient in whom immunological defenses are severely impaired. This major problem is thefocus of attention in this book, based on the presentation of the First International Congress on the Immune Consequences of Trauma, Shock, and Sepsis, which is one of the first attempts to exchange ideas on the state-of-the-art in this area of immunology. Both basic and clinical research, including new centres of attention, are described. ...

Over two decades an abundance of knowledge has been accumulated focus ing on the understanding of the molecular and cellular pathomechanisms of stressful conditions like systemic inflammation and sepsis. We have learned that there is a clear correlation between the magnitude of the inciting traumatic event and the degree of inflammatory dysbalance. The immunoinflammatory disintegration comprises a simultaneous col lapse of the otherwise very smoothly balanced pro- and antiinflammatory vect...

Inflammation in itself is not to be considered as a disease . . . and in disease, where it can alter the diseased mode of action, it likewise leads to a cure; but where it cannot accomplish that solitary purpose . . . it does mischief - John Hunter, A Treatise on the Blood, ITfIlammation, and Gunshot Woundr (London, 1794)1 As we reached the millennium, we recognized the gap between our scientific knowledge of biologic processes and our more limited clinical capabilities in the care of pati...

The Yearbook compiles the most recent developments in experimental andclinical research and practice in one comprehensive reference book. Thechapters are written by well recognized experts in the field of intensive care and emergency medicine. It is addressed to everyone involved in internal medicine, anesthesia, surgery, pediatrics, intensive care and emergency medicine.

This third edition texthas been largely rewritten to include the many important advances that have been made and the controversies that have arisen in the past years. New topics have been added including Oxygen Transport, Tissue Oxygenation Evaluation, Echocardiography in the Critically Ill, Bedside Ultrasonography, Critical Care Issues in Oncological Surgery Patients, Long-Term Outcome after Intensive Care, Therapeutic Hypothermia, Delirium, and Post-Operative Gastrointestinal Dysfunction...

The Yearbook compiles the most recent developments in experimental and clinical research and practice in one comprehensive reference book. The chapters are written by well recognized experts in the field of intensive care and emergency medicine. It is addressed to everyone involved in internal medicine, anesthesia, surgery, pediatrics, intensive care and emergency medicine.

The conditions of Crohn’s disease and ulcerative colitis are excellent examples of how the exponential growth of knowledge in biomedical science can make a remarkable impact on clinical practice and patient’s quality of life. It has led to the development of unique novel immunomodulatory treatments. These are continuously being refined to treat not only the two original conditions in the gut, but the systemic immunologic illness with its associated extraintestinal disorders. New therapies ...

Patients with a range of medical conditions undergo surgeries of varying levels of risk, and the evolving field of consult medicine aims to address their needs, whether pre- or post-surgery. This new edition of The Perioperative Medicine Consult Handbook provides useful information, advice, and guidelines based on a combination of clinical experience and evidence-based medicine. It covers topics in many major clinical areas (anesthesiology, cardiology, pulmonology, gastroenterolog...

Pain is one of the most common symptoms of neurological disease and its appropriate management is essential to the effective care of patients. Neurological disorders differ in their specific pain phenotype, mechanisms and therapy. Case Studies in Neurological Pain addresses the specific pain issues, treatment and pathophysiology in patients with a wide spectrum of neurological disease. Clinical case studies have long been recognized as a useful adjunct to problem-based learning and continu...

The Essential Guide for Clinicians Who Prescribe and Inject BoNTsThis is a detailed and practical guide to botulinum neurotoxin therapy (BoNT) and the wide range of applications for neurological and pain disorders. A unique reference source for new injectors and experienced clinicians alike, this indispensable manual provides information on dose, dilution, and indications for all four FDA-approved toxins in one handy text.Following a brief review o...

The first book focusing specifically on frequent and frequently disabling side effects involving the skin, hair and nails in cancer patientsAccording to the World Health Organization, there are approximately thirty million people living with a diagnosis of cancer – the majority of whom will receive surgery, systemic therapy, and/or radiation, and who will suffer from dermatologic adverse events. Dermatologists and oncologists are only beginning to grapple with thes...

Palliative surgery can greatly contribute to improving symptom control and quality of life for terminal cancer patients. Owing to the advanced stage of the disease, however, this type of surgery is also associated with significant morbidity and mortality. It is therefore important for surgeons to have a sound understanding of the medical and scientific background underlying treatment decisions in palliative surgery, a foundation that this book provides. The opening chapters examine the rel...