Reproducibility is fundamental to the scientific method. After reading a paper describing research findings, a scientist should be able to repeat the experiment and obtain the same results. Yet an alarming number—perhaps as high as 90 percent—of published biomedical research papers face challenges in independent replication. Such issues range from honest mistakes to outright fraud. The scope of this crisis, however, underscores deeper systemic issues within the scientific community: its cu...

Poly (ADP-ribose) polymerase (PARP), also termed poly (ADP-ribose) synthetase (PARS) is a nuclear enzyme with a wide range of functions, including regulation of DNA repair, cell differentiation, and gene expression. More than a decade after the identification of PARP-like enzymatic activities in mammalian cells, a novel role was proposed for this e

The Danubian provinces represent one of the largest macro-units within the Roman Empire, with a large and rich heritage of Roman material evidence. Although the notion itself is a modern 18th-century creation, this region represents a unique area, where the dominant, pre-Roman cultures (Celtic, Illyrian, Hellenistic, Thracian) are interconnected within the new administrative, economic and cultural units of Roman cities, provinces and extra-provincial networks. This book presents the materi...

Hydrogen sulfide (H2S) was first reported in the biomedical literature as a toxicant/pollutant and for decades it remained an agent solely of toxicological interest. More recently, H2S was shown to be produced by mammalian tissues. The present book summarizes the basic principles of H2S chemistry and biology and extends to the most recent breakthroughs in the field, bringing the reader up to date with developments on this gasotransmitter. The chapters from expert contributors are organised...

After a century of research, several lines of evidence now indicate that the ability of adenosine to directly control inflammatory cells has a major impact on the functions of the inflammatory and immune systems. Consequently, many promising therapeutic approaches are beginning to emerge that focus on the modulation of adenosine, including the deve