This book constitutes the proceedings of the 18th International Conference on Informatics in Schools: Situation, Evolution, and Perspectives, ISSEP 2025, held in Trier, Germany, during September 8–10, 2025.The 13 full papers presented were carefully reviewed and selected from 41 submissions. The papers cover the following topics: Curricula and Computer Science Concepts; Teachers’ Perspective; AI and Digital Literacy; Programming, Problem Solving, and Computational Thinking.